Structure, function, and pharmacology of glutamate receptor ion channels

KB Hansen, LP Wollmuth, D Bowie, H Furukawa… - Pharmacological …, 2021 - Elsevier
Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

IRES-mediated cap-independent translation, a path leading to hidden proteome

Y Yang, Z Wang - Journal of molecular cell biology, 2019 - academic.oup.com
Most eukaryotic mRNAs are translated in a cap-dependent fashion; however, under stress
conditions, the cap-independent translation driven by internal ribosomal entry sites (IRESs) …

The protein expression profile of ACE2 in human tissues

F Hikmet, L Méar, Å Edvinsson, P Micke… - Molecular systems …, 2020 - embopress.org
The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …

The ProteomeXchange consortium in 2020: enabling 'big data'approaches in proteomics

EW Deutsch, N Bandeira, V Sharma… - Nucleic acids …, 2020 - academic.oup.com
The ProteomeXchange (PX) consortium of proteomics resources (http://www.
proteomexchange. org) has standardized data submission and dissemination of mass …

The PRIDE database and related tools and resources in 2019: improving support for quantification data

Y Perez-Riverol, A Csordas, J Bai… - Nucleic acids …, 2019 - academic.oup.com
Abstract The PRoteomics IDEntifications (PRIDE) database (https://www. ebi. ac. uk/pride/) is
the world's largest data repository of mass spectrometry-based proteomics data, and is one …

Mass-spectrometry-based draft of the Arabidopsis proteome

J Mergner, M Frejno, M List, M Papacek, X Chen… - Nature, 2020 - nature.com
Plants are essential for life and are extremely diverse organisms with unique molecular
capabilities. Here we present a quantitative atlas of the transcriptomes, proteomes and …

Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture

GG Giobbe, C Crowley, C Luni, S Campinoti… - Nature …, 2019 - nature.com
Organoids have extensive therapeutic potential and are increasingly opening up new
avenues within regenerative medicine. However, their clinical application is greatly limited …

A deep proteome and transcriptome abundance atlas of 29 healthy human tissues

D Wang, B Eraslan, T Wieland, B Hallström… - Molecular systems …, 2019 - embopress.org
Abstract Genome‐, transcriptome‐and proteome‐wide measurements provide insights into
how biological systems are regulated. However, fundamental aspects relating to which …

Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning

S Gessulat, T Schmidt, DP Zolg, P Samaras… - Nature …, 2019 - nature.com
In mass-spectrometry-based proteomics, the identification and quantification of peptides and
proteins heavily rely on sequence database searching or spectral library matching. The lack …

Meltome atlas—thermal proteome stability across the tree of life

A Jarzab, N Kurzawa, T Hopf, M Moerch, J Zecha… - Nature …, 2020 - nature.com
We have used a mass spectrometry-based proteomic approach to compile an atlas of the
thermal stability of 48,000 proteins across 13 species ranging from archaea to humans and …