Plants have evolved sophisticated mechanisms to recycle intracellular constituents, which
are essential for developmental and metabolic transitions; for efficient nutrient reuse; and for …

Since the first monoclonal antibody drug, muromonab-CD3, was approved for marketing in
1986, 165 antibody drugs have been approved or are under regulatory review worldwide …

Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification …

Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current
treatments exclusively target host inflammatory pathways. To understand how host …

Microbial organisms have key roles in numerous physiological processes in the human
body and have recently been shown to modify the response to immune checkpoint …

Sequence logos are visually compelling ways of illustrating the biological properties of DNA,
RNA and protein sequences, yet it is currently difficult to generate and customize such logos …

Metabolism-mediated epigenetic changes represent an adapted mechanism for cellular
signaling, in which lysine acetylation and methylation have been the historical focus of …

Ubiquitination is a post-translational modification (PTM) that is essential for balancing
numerous physiological processes. To enable delineation of protein ubiquitination at a site …

The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators. Here,
we combined quantitative proteomics with CBP/p300-specific catalytic inhibitors …

Numerous substrates have been identified for Type I and II arginine methyltransferases
(PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its …