Highlights•Locked nucleic acid-modified antisense oligonucleotides (LNAs) bind to and
modulate RNA.•The high binding affinity of LNAs significantly improves potency.•Structural …

Oligonucleotide chemistry has been developed greatly over the past three decades, with
many advances in increasing nuclease resistance, enhancing duplex stability and assisting …

Nucleosides are the building blocks required in constructing nucleic acids. As we learned in
school, billions of combinations are possible using only four different nucleosides, and thus …

Fluorescence in situ hybridization (FISH) is a well-established technique that is used for a
variety of purposes, ranging from pathogen detection in clinical diagnostics to the …

The present invention provides improved oligomeric com pound, in particular
oligonucleotide compounds, and meth ods for modulating the expression of the Bcl-2 gene …

First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
40526747&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Over the past 25 years, the acceleration of achievements in the development of
oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the …

The present invention provides compositions and methods of treatment of diseases that are
sensitive to drugs that downregulate the function of microRNA's, mRNA, non-coding RNA, or …

Conspectus Incorporation of chemically modified nucleotide scaffolds into nucleic acids to
form assemblies rich in function is an innovative area with great promise for nanotechnology …

Locked nucleic acid (β‐d‐LNA) monomers are conformationally restricted nucleotides
bearing a methylene 2′‐O, 4′‐C linkage that have an unprecedented high affinity for …