Caspases are proteolytic enzymes that belong to the cysteine protease family and play a
crucial role in homeostasis and programmed cell death. Caspases have been broadly …

Caspases are a family of conserved cysteine proteases that play key roles in programmed
cell death and inflammation. In multicellular organisms, caspases are activated via …

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated
guidelines for the definition and interpretation of cell death from morphological, biochemical …

Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …

Caspases are proteases with a well-defined role in apoptosis. However, increasing
evidence indicates multiple functions of caspases outside apoptosis. Caspase-1 and …

Inflammatory and apoptotic caspases are central players in inflammation and apoptosis,
respectively. However, recent studies have revealed that these caspases have functions …

Abstract In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of
recommendations for the definition of distinct cell death morphologies and for the …

Some forms of regulated cell death, such as apoptosis, are precipitated by the activation of
cysteine proteases of the caspase family, including caspase 8, 9, and 3. Other caspases …

Epidermal keratinocytes undergo a unique form of terminal differentiation and programmed
cell death known as cornification. Cornification leads to the formation of the outermost skin …

The epidermis functions as a barrier against the environment by means of several layers of
terminally differentiated, dead keratinocytes—the cornified layer, which forms the endpoint of …