Biological imaging of chemical bonds by stimulated Raman scattering microscopy

F Hu, L Shi, W Min - Nature methods, 2019 - nature.com
All molecules consist of chemical bonds, and much can be learned from map** the
spatiotemporal dynamics of these bonds. Since its invention a decade ago, stimulated …

Applications of Raman spectroscopy in cancer diagnosis

GW Auner, SK Koya, C Huang, B Broadbent… - Cancer and Metastasis …, 2018 - Springer
Novel approaches toward understanding the evolution of disease can lead to the discovery
of biomarkers that will enable better management of disease progression and improve …

Virtual formalin-fixed and paraffin-embedded staining of fresh brain tissue via stimulated Raman CycleGAN model

Z Liu, L Chen, H Cheng, J Ao, J **ong, X Liu… - Science …, 2024 - science.org
Intraoperative histology is essential for surgical guidance and decision-making. However,
frozen-sectioned hematoxylin and eosin (H&E) staining suffers from degraded accuracy …

Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

TC Hollon, B Pandian, AR Adapa, E Urias, AV Save… - Nature medicine, 2020 - nature.com
Intraoperative diagnosis is essential for providing safe and effective care during cancer
surgery. The existing workflow for intraoperative diagnosis based on hematoxylin and eosin …

Light in diagnosis, therapy and surgery

SH Yun, SJJ Kwok - Nature biomedical engineering, 2017 - nature.com
Light and optical techniques have made profound impacts on modern medicine, with
numerous lasers and optical devices currently being used in clinical practice to assess …

Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy

DA Orringer, B Pandian, YS Niknafs… - Nature biomedical …, 2017 - nature.com
Conventional methods for intraoperative histopathologic diagnosis are labour-and time-
intensive, and may delay decision-making during brain-tumour surgery. Stimulated Raman …

Instant diagnosis of gastroscopic biopsy via deep-learned single-shot femtosecond stimulated Raman histology

Z Liu, W Su, J Ao, M Wang, Q Jiang, J He, H Gao… - Nature …, 2022 - nature.com
Gastroscopic biopsy provides the only effective method for gastric cancer diagnosis, but the
gold standard histopathology is time-consuming and incompatible with gastroscopy …

Maximizing safe resection of low-and high-grade glioma

SL Hervey-Jumper, MS Berger - Journal of neuro-oncology, 2016 - Springer
Surgical resection plays a central role in the management of gliomas. In this study, we
review the evidence in support of extent of resection to improve survival, symptom …

Raman spectroscopy: techniques and applications in the life sciences

DW Shipp, F Sinjab, I Notingher - Advances in Optics and Photonics, 2017 - opg.optica.org
Raman spectroscopy is an increasingly popular technique in many areas, including biology
and medicine. It is based on Raman scattering, a phenomenon in which incident photons …

Bond-selective imaging by optically sensing the mid-infrared photothermal effect

Y Bai, J Yin, JX Cheng - Science advances, 2021 - science.org
Mid-infrared (IR) spectroscopic imaging using inherent vibrational contrast has been broadly
used as a powerful analytical tool for sample identification and characterization. However …