Pioneer transcription factors: establishing competence for gene expression
Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …
and target the assembly of protein complexes that control gene expression. Yet much of the …
Emerging roles of linker histones in regulating chromatin structure and function
Together with core histones, which make up the nucleosome, the linker histone (H1) is one
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …
of the five main histone protein families present in chromatin in eukaryotic cells. H1 binds to …
Extreme disorder in an ultrahigh-affinity protein complex
Molecular communication in biology is mediated by protein interactions. According to the
current paradigm, the specificity and affinity required for these interactions are encoded in …
current paradigm, the specificity and affinity required for these interactions are encoded in …
Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming
Pioneer transcription factors (TFs) access silent chromatin and initiate cell-fate changes,
using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a …
using diverse types of DNA binding domains (DBDs). FoxA, the paradigm pioneer TF, has a …
Intrinsic disorder and protein function
The dominant view of protein structure-function is that an amino acid sequence specifies a
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
three-dimensional (3-D) structure that is a prerequisite for protein function. In contrast, many …
Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5
KL Clark, ED Halay, E Lai, SK Burley - Nature, 1993 - nature.com
The three-dimensional structure of an HNF-3/fork head DNA-recognition motif complexed
with DNA has been determined by X-ray crystallography at 2.5 Å resolution. This α/β protein …
with DNA has been determined by X-ray crystallography at 2.5 Å resolution. This α/β protein …
Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4
LA Cirillo, FR Lin, I Cuesta, D Friedman, M Jarnik… - Molecular cell, 2002 - cell.com
The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the
albumin gene enhancer in liver precursor cells in embryos. To understand how they access …
albumin gene enhancer in liver precursor cells in embryos. To understand how they access …
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma
Follicular lymphoma is an incurable malignancy, with transformation to an aggressive
subtype representing a critical event during disease progression. Here we performed whole …
subtype representing a critical event during disease progression. Here we performed whole …
[CITATION][C] Chromatin: Structure and Function
AP Wolffe - 1998 - books.google.com
The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …
remarkable progress in chromatin research over the past three years. It has been …
[HTML][HTML] A brief review of nucleosome structure
AR Cutter, JJ Hayes - FEBS letters, 2015 - Elsevier
The nucleosomal subunit organization of chromatin provides a multitude of functions.
Nucleosomes elicit an initial∼ 7-fold linear compaction of genomic DNA. They provide a …
Nucleosomes elicit an initial∼ 7-fold linear compaction of genomic DNA. They provide a …