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Advances in extracellular vesicle nanotechnology for precision theranostics
Q Wu, S Fu, H **ao, J Du, F Cheng, S Wan… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) have increasingly been recognized as important cell surrogates
influencing many pathophysiological processes, including cellular homeostasis, cancer …
influencing many pathophysiological processes, including cellular homeostasis, cancer …
Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing
Clustered regularly interspaced palindromic repeats (CRISPR) is a gene editing tool with
tremendous therapeutic potential. Recently, ribonucleoprotein (RNP) complex‐based …
tremendous therapeutic potential. Recently, ribonucleoprotein (RNP) complex‐based …
Engineered extracellular vesicle-delivered CRISPR/Cas9 for radiotherapy sensitization of glioblastoma
X Liu, Z Cao, W Wang, C Zou, Y Wang, L Pan, B Jia… - ACS …, 2023 - ACS Publications
Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development of
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …
CRISPR–Cas9 applications in T cells and adoptive T cell therapies
X Chen, S Zhong, Y Zhan, X Zhang - Cellular & molecular biology letters, 2024 - Springer
T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing
immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can …
immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can …
The Biosynthesis and Applications of Protein Lipidation
W Ding, J Gu, W Xu, J Wu, Y Huang, S Zhang… - Chemical …, 2024 - ACS Publications
Protein lipidation dramatically affects protein structure, localization, and trafficking via
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …
CRISPR-Cas9 delivery strategies with engineered extracellular vesicles
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic
mutations in tissues and cells. Recent progress in the CRISPR-Cas9 systems has led to …
mutations in tissues and cells. Recent progress in the CRISPR-Cas9 systems has led to …
The CRISPR/Cas9 system delivered by extracellular vesicles
X Zhu, M Gao, Y Yang, W Li, J Bao, Y Li - Pharmaceutics, 2023 - mdpi.com
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems can precisely manipulate DNA sequences to change the …
protein (Cas) systems can precisely manipulate DNA sequences to change the …
Functionalized extracellular nanovesicles as advanced CRISPR delivery systems
The clustered regularly interspaced short palindromic repeat (CRISPR) system, an emerging
tool for genome editing, has garnered significant public interest for its potential in treating …
tool for genome editing, has garnered significant public interest for its potential in treating …
[HTML][HTML] Extracellular vesicles: The next generation of biomarkers and treatment for central nervous system diseases
G Zanirati, PG Dos Santos, AM Alcará, F Bruzzo… - International Journal of …, 2024 - mdpi.com
It has been widely established that the characterization of extracellular vesicles (EVs),
particularly small EVs (sEVs), shed by different cell types into biofluids, helps to identify …
particularly small EVs (sEVs), shed by different cell types into biofluids, helps to identify …
Extracellular vesicles as a potential delivery platform for CRISPR-Cas based therapy in epithelial ovarian cancer
Ovarian Cancer (OC) is the most common gynecological malignancy and the eighth most
diagnosed cancer in females worldwide. Presently, it ranks as the fifth leading cause of …
diagnosed cancer in females worldwide. Presently, it ranks as the fifth leading cause of …