Advances in extracellular vesicle nanotechnology for precision theranostics

Q Wu, S Fu, H **ao, J Du, F Cheng, S Wan… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) have increasingly been recognized as important cell surrogates
influencing many pathophysiological processes, including cellular homeostasis, cancer …

Engineering extracellular vesicles to deliver CRISPR ribonucleoprotein for gene editing

JA Whitley, H Cai - Journal of Extracellular Vesicles, 2023 - Wiley Online Library
Clustered regularly interspaced palindromic repeats (CRISPR) is a gene editing tool with
tremendous therapeutic potential. Recently, ribonucleoprotein (RNP) complex‐based …

Engineered extracellular vesicle-delivered CRISPR/Cas9 for radiotherapy sensitization of glioblastoma

X Liu, Z Cao, W Wang, C Zou, Y Wang, L Pan, B Jia… - ACS …, 2023 - ACS Publications
Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development of
therapeutic resistance has hampered the efficacy of radiotherapy, suggesting that additional …

CRISPR–Cas9 applications in T cells and adoptive T cell therapies

X Chen, S Zhong, Y Zhan, X Zhang - Cellular & molecular biology letters, 2024 - Springer
T cell immunity is central to contemporary cancer and autoimmune therapies, encompassing
immune checkpoint blockade and adoptive T cell therapies. Their diverse characteristics can …

The Biosynthesis and Applications of Protein Lipidation

W Ding, J Gu, W Xu, J Wu, Y Huang, S Zhang… - Chemical …, 2024 - ACS Publications
Protein lipidation dramatically affects protein structure, localization, and trafficking via
remodeling protein–membrane and protein–protein interactions through hydrophobic lipid …

CRISPR-Cas9 delivery strategies with engineered extracellular vesicles

Y Lu, K Godbout, G Lamothe, JP Tremblay - Molecular Therapy-Nucleic …, 2023 - cell.com
Therapeutic genome editing has the potential to cure diseases by directly correcting genetic
mutations in tissues and cells. Recent progress in the CRISPR-Cas9 systems has led to …

The CRISPR/Cas9 system delivered by extracellular vesicles

X Zhu, M Gao, Y Yang, W Li, J Bao, Y Li - Pharmaceutics, 2023 - mdpi.com
Clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated
protein (Cas) systems can precisely manipulate DNA sequences to change the …

Functionalized extracellular nanovesicles as advanced CRISPR delivery systems

S Wang, H Kong, C Zhuo, L Liu, S Lv, D Cheng… - Biomaterials …, 2024 - pubs.rsc.org
The clustered regularly interspaced short palindromic repeat (CRISPR) system, an emerging
tool for genome editing, has garnered significant public interest for its potential in treating …

[HTML][HTML] Extracellular vesicles: The next generation of biomarkers and treatment for central nervous system diseases

G Zanirati, PG Dos Santos, AM Alcará, F Bruzzo… - International Journal of …, 2024 - mdpi.com
It has been widely established that the characterization of extracellular vesicles (EVs),
particularly small EVs (sEVs), shed by different cell types into biofluids, helps to identify …

Extracellular vesicles as a potential delivery platform for CRISPR-Cas based therapy in epithelial ovarian cancer

N Godbole, A Quinn, F Carrion, E Pelosi… - Seminars in Cancer …, 2023 - Elsevier
Ovarian Cancer (OC) is the most common gynecological malignancy and the eighth most
diagnosed cancer in females worldwide. Presently, it ranks as the fifth leading cause of …