Long noncoding RNAs in cancer: mechanisms of action and technological advancements
The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to
being defined as a category of genetic elements, leaving its mark on the field of cancer …
being defined as a category of genetic elements, leaving its mark on the field of cancer …
The H19 Long non-coding RNA in cancer initiation, progression and metastasis–a proposed unifying theory
E Raveh, IJ Matouk, M Gilon, A Hochberg - Molecular cancer, 2015 - Springer
The imprinted oncofetal long non-coding RNA (lncRNA) H19 is expressed in the embryo,
down-regulated at birth and then reappears in tumors. Its role in tumor initiation and …
down-regulated at birth and then reappears in tumors. Its role in tumor initiation and …
Targeting YAP-dependent MDSC infiltration impairs tumor progression
The signaling mechanisms between prostate cancer cells and infiltrating immune cells may
illuminate novel therapeutic approaches. Here, utilizing a prostate adenocarcinoma model …
illuminate novel therapeutic approaches. Here, utilizing a prostate adenocarcinoma model …
Long noncoding RNAs in cancer and therapeutic potential
Long noncoding RNAs (lncRNAs) are the major elements of the mammalian transcriptome
that is emerging as a central player controlling diverse cellular mechanisms. Most of the well …
that is emerging as a central player controlling diverse cellular mechanisms. Most of the well …
Prostate organogenesis: tissue induction, hormonal regulation and cell type specification
Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …
Long noncoding RNAs in cardiac development and ageing
Nature Reviews Cardiology, 2015 - nature.com
A large part of the mammalian genome is transcribed into noncoding RNAs. Long
noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene …
noncoding RNAs (lncRNAs) have emerged as critical epigenetic regulators of gene …
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
W Tao, Z Yu, JDJ Han - Cell Metabolism, 2024 - cell.com
Cellular senescence underlies many aging-related pathologies, but its heterogeneity poses
challenges for studying and targeting senescent cells. We present here a machine learning …
challenges for studying and targeting senescent cells. We present here a machine learning …
Cellular and molecular mechanisms underlying prostate cancer development: therapeutic implications
Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …
H19 lncRNA alters DNA methylation genome wide by regulating S-adenosylhomocysteine hydrolase
DNA methylation is essential for mammalian development and physiology. Here we report
that the developmentally regulated H19 lncRNA binds to and inhibits S …
that the developmentally regulated H19 lncRNA binds to and inhibits S …
Intragenic antagonistic roles of protein and circRNA in tumorigenesis
Abstract circRNAs arise from back splicing events during mRNA processing, and when
deregulated can play an active role in cancer. Here we characterize a new circRNA …
deregulated can play an active role in cancer. Here we characterize a new circRNA …