The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Background: Dysregulated stress neurocircuits, caused by genetic and/or environmental
changes, underlie the development of many neuropsychiatric disorders. Corticotropin …

Corticotropin-releasing hormone (CRH) is a central integrator in the brain of endocrine and
behavioral stress responses, whereas activation of the endocannabinoid CB1 receptor …

Single-nucleotide polymorphisms (SNPs) in CACNA1C, the α1C subunit of the voltage-
gated L-type calcium channel Ca v 1.2, rank among the most consistent and replicable …

Background Resistance to antidepressant drug treatment remains a major health problem.
Animal models of depression are efficient in detecting effective treatments but have done …

Two major and mutually interconnected brain systems are recruited during stress reaction.
One is the hypothalamic paraventricular nucleus (PVH) and the second is the extended …

Major depressive disorder (MDD) is a devastating disease affecting over 300 million people
worldwide, and costing an estimated 380 billion Euros in lost productivity and health care in …

Resilience to stress-related emotional disorders is governed in part by early-life
experiences. Here we demonstrate experience-dependent re-programming of stress …

Exposure to prenatal stress (PNS) can lead to long-lasting neurobiological and behavioral
consequences for the offspring, which may enhance the susceptibility for mental disorders …

Abstract Objective Metabolic Syndrome, which can be induced or exacerbated by current
antipsychotic drugs (APDs), is highly prevalent in schizophrenia patients. Recent preclinical …