Mitochondrial energetic adaptations encompass a plethora of conserved processes that
maintain cell and organismal fitness and survival in the changing environment by adjusting …

Over the past decade, it has become clear that lipid homeostasis is central to cellular
metabolism. Lipids are particularly abundant in the central nervous system (CNS) where …

Although it is well described that mitochondria are at the epicentre of the energy demands of
a cell, it is becoming important to consider how each cell tailors its mitochondrial …

Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often
beneficial to energy expenditure; however, increased circulating levels of BCAA are linked …

Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Thermogenesis by uncoupling protein 1 (UCP1) is one of the primary mechanisms by which
brown adipose tissue (BAT) increases energy expenditure. UCP1 resides in the inner …