Targeting RNA structures with small molecules
JL Childs-Disney, X Yang, QMR Gibaut… - Nature Reviews Drug …, 2022 - nature.com
RNA adopts 3D structures that confer varied functional roles in human biology and
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
dysfunction in disease. Approaches to therapeutically target RNA structures with small …
Rock, scissors, paper: How RNA structure informs function
RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …
[HTML][HTML] Programming inactive RNA-binding small molecules into bioactive degraders
Target occupancy is often insufficient to elicit biological activity, particularly for RNA,
compounded by the longstanding challenges surrounding the molecular recognition of RNA …
compounded by the longstanding challenges surrounding the molecular recognition of RNA …
RNA genome conservation and secondary structure in SARS-CoV-2 and SARS-related viruses: a first look
R Rangan, IN Zheludev, RJ Hagey, EA Pham… - Rna, 2020 - rnajournal.cshlp.org
As the COVID-19 outbreak spreads, there is a growing need for a compilation of conserved
RNA genome regions in the SARS-CoV-2 virus along with their structural propensities to …
RNA genome regions in the SARS-CoV-2 virus along with their structural propensities to …
How we think about targeting RNA with small molecules
MG Costales, JL Childs-Disney, HS Haniff… - Journal of medicinal …, 2020 - ACS Publications
RNA offers nearly unlimited potential as a target for small molecule chemical probes and
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …
lead medicines. Many RNAs fold into structures that can be selectively targeted with small …
Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread
A promising approach to tackle the severe acute respiratory syndrome coronavirus-2 (SARS-
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
CoV-2) could be small interfering (si) RNAs. So far it is unclear, which viral replication steps …
Comprehensive map** of SARS-CoV-2 interactions in vivo reveals functional virus-host interactions
SARS-CoV-2 is a major threat to global health. Here, we investigate the RNA structure and
RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using …
RNA-RNA interactions of wildtype (WT) and a mutant (Δ382) SARS-CoV-2 in cells using …
Transcriptome-Wide Map** of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA
The interactions between cellular RNAs in MDA-MB-231 triple negative breast cancer cells
and a panel of small molecules appended with a diazirine cross-linking moiety and an …
and a panel of small molecules appended with a diazirine cross-linking moiety and an …
A map of the SARS-CoV-2 RNA structurome
SARS-CoV-2 has exploded throughout the human population. To facilitate efforts to gain
insights into SARS-CoV-2 biology and to target the virus therapeutically, it is essential to …
insights into SARS-CoV-2 biology and to target the virus therapeutically, it is essential to …
To knot or not to knot: multiple conformations of the SARS-CoV-2 frameshifting RNA element
The SARS-CoV-2 frameshifting RNA element (FSE) is an excellent target for therapeutic
intervention against Covid-19. This small gene element employs a shifting mechanism to …
intervention against Covid-19. This small gene element employs a shifting mechanism to …