Sonogenetics for monitoring and modulating biomolecular function by ultrasound

J Hahmann, A Ishaqat, T Lammers… - Angewandte Chemie …, 2024 - Wiley Online Library
Ultrasound technology, synergistically harnessed with genetic engineering and chemistry
concepts, has started to open the gateway to the remarkable realm of sonogenetics—a …

Exploiting the mechanical effects of ultrasound for noninvasive therapy

MA O'Reilly - Science, 2024 - science.org
Focused ultrasound is a platform technology capable of eliciting a wide range of biological
responses with high spatial precision deep within the body. Although focused ultrasound is …

Nanobubble-actuated ultrasound neuromodulation for selectively sha** behavior in mice

X Hou, J **g, Y Jiang, X Huang, Q **an, T Lei… - Nature …, 2024 - nature.com
Ultrasound is an acoustic wave which can noninvasively penetrate the skull to deep brain
regions, enabling neuromodulation. However, conventional ultrasound's spatial resolution is …

Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology

KR Murphy, JS Farrell, J Bendig, A Mitra, C Luff… - Neuron, 2024 - cell.com
Focused ultrasound can non-invasively modulate neural activity, but whether effective
stimulation parameters generalize across brain regions and cell types remains unknown …

Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow

XR Lim, MM Abd-Alhaseeb, M Ippolito, M Koide… - Nature …, 2024 - nature.com
Hyperemia in response to neural activity is essential for brain health. A hyperemic response
delivers O2 and nutrients, clears metabolic waste, and concomitantly exposes …

[HTML][HTML] Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system

B Zong, F Yu, X Zhang, Y Pang, W Zhao, P Sun… - Ageing Research …, 2023 - Elsevier
Since the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a
significant amount of research conducted to explore its regulatory role in the physiology and …

Acoustic virtual 3D scaffold for direct-interacting tumor organoid–immune cell coculture systems

H Shan, M Chen, S Zhao, X Wei, M Zheng, Y Li… - Science …, 2024 - science.org
Three-dimensional (3D) cell culture has revolutionized life sciences, particularly in organoid
technologies. Traditional bioscaffold materials, however, complicate the detachment of …

Low-intensity focused ultrasound for human neuromodulation

W Legon, A Strohman - Nature Reviews Methods Primers, 2024 - nature.com
Low-intensity focused ultrasound (LIFU) is a potentially transformative form of human non-
invasive neuromodulation that provides millimetre-sized focal volumes combined with …

[HTML][HTML] The relationship between parameters and effects in transcranial ultrasonic stimulation.

T Nandi, BR Kop, KB Pauly, CJ Stagg, L Verhagen - Brain Stimulation, 2024 - Elsevier
Transcranial ultrasonic stimulation (TUS) is rapidly gaining traction for non-invasive human
neuromodulation, with a pressing need to establish protocols that maximise …

[HTML][HTML] Transcranial focused ultrasound stimulation in the infralimbic cortex facilitates extinction of conditioned fear in rats

J Lee, YE Kim, J Lim, Y Jo, HJ Lee, YS Jo, JS Choi - Brain Stimulation, 2024 - Elsevier
Transcranial focused ultrasound (tFUS) neuromodulation emerges as a promising non-
invasive approach for improving neurological conditions. Extinction of conditioned fear has …