As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

Cell death is critical for the development and homeostasis of almost all multicellular
organisms. Moreover, its dysregulation leads to diverse disease states. Historically …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

The NLRP3 inflammasome is linked to sterile and pathogen-dependent inflammation, and
its dysregulation underlies many chronic diseases. Mitochondria have been implicated as …

The mammalian NLR gene family was first reported over 20 years ago, although several
genes that were later grouped into the family were already known at that time. Although it is …

Cell death is a fundamental physiological process in all living organisms. Its roles extend
from embryonic development, organ maintenance, and aging to the coordination of immune …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

The process of pyroptosis is mediated by inflammasomes and a downstream effector known
as gasdermin D (GSDMD). Upon cleavage by inflammasome-associated caspases, the N …

Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …