Sulfhydryl groups as targets of mercury toxicity

OP Ajsuvakova, AA Tinkov, M Aschner… - Coordination chemistry …, 2020 - Elsevier
The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …

The toxicology of mercury: Current research and emerging trends

G Bjørklund, M Dadar, J Mutter, J Aaseth - Environmental research, 2017 - Elsevier
Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical
properties of public health concern since their natural and anthropogenic diffusions still …

The human SLC1A5 (ASCT2) amino acid transporter: from function to structure and role in cell biology

M Scalise, L Pochini, L Console, MA Losso… - Frontiers in cell and …, 2018 - frontiersin.org
SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …

The toxicology of mercury and its compounds

T Syversen, P Kaur - Journal of Trace Elements in Medicine and Biology, 2012 - Elsevier
A concentrated review on the toxicology of inorganic mercury together with an extensive
review on the neurotoxicology of methylmercury is presented. The challenges of using …

Biomarkers of mercury toxicity: Past, present, and future trends

V Branco, S Caito, M Farina… - Journal of Toxicology …, 2017 - Taylor & Francis
Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …

Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health

L Pochini, M Scalise, M Galluccio, C Indiveri - Frontiers in chemistry, 2014 - frontiersin.org
Glutamine together with glucose is essential for body's homeostasis. It is the most abundant
amino acid and is involved in many biosynthetic, regulatory and energy production …

Target the human alanine/serine/cysteine transporter 2 (ASCT2): achievement and future for novel cancer therapy

H Jiang, N Zhang, T Tang, F Feng, H Sun… - Pharmacological …, 2020 - Elsevier
Glutamine metabolism, described as major energy and building blocks supply to cell growth,
has gained great attention. Alanine-Serine-Cysteine Transporter (ASCT2), which belongs to …

Rational design of ASCT2 inhibitors using an integrated experimental-computational approach

RAA Garibsingh, E Ndaru, AA Garaeva, Y Shi… - Proceedings of the …, 2021 - pnas.org
ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino
acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates …

The concise guide to pharmacology 2013/14: transporters

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

OCTN cation transporters in health and disease: role as drug targets and assay development

L Pochini, M Scalise, M Galluccio… - Journal of …, 2013 - journals.sagepub.com
The three members of the organic cation transporter novel subfamily are known to be
involved in interactions with xenobiotic compounds. These proteins are characterized by 12 …