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Sulfhydryl groups as targets of mercury toxicity
The present study addresses existing data on the affinity and conjugation of sulfhydryl (thiol;-
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …
SH) groups of low-and high-molecular-weight biological ligands with mercury (Hg). The …
The toxicology of mercury: Current research and emerging trends
Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical
properties of public health concern since their natural and anthropogenic diffusions still …
properties of public health concern since their natural and anthropogenic diffusions still …
The human SLC1A5 (ASCT2) amino acid transporter: from function to structure and role in cell biology
SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …
The toxicology of mercury and its compounds
T Syversen, P Kaur - Journal of Trace Elements in Medicine and Biology, 2012 - Elsevier
A concentrated review on the toxicology of inorganic mercury together with an extensive
review on the neurotoxicology of methylmercury is presented. The challenges of using …
review on the neurotoxicology of methylmercury is presented. The challenges of using …
Biomarkers of mercury toxicity: Past, present, and future trends
Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …
populations are mostly exposed to low chronic levels of mercurial compounds …
Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health
Glutamine together with glucose is essential for body's homeostasis. It is the most abundant
amino acid and is involved in many biosynthetic, regulatory and energy production …
amino acid and is involved in many biosynthetic, regulatory and energy production …
Target the human alanine/serine/cysteine transporter 2 (ASCT2): achievement and future for novel cancer therapy
H Jiang, N Zhang, T Tang, F Feng, H Sun… - Pharmacological …, 2020 - Elsevier
Glutamine metabolism, described as major energy and building blocks supply to cell growth,
has gained great attention. Alanine-Serine-Cysteine Transporter (ASCT2), which belongs to …
has gained great attention. Alanine-Serine-Cysteine Transporter (ASCT2), which belongs to …
Rational design of ASCT2 inhibitors using an integrated experimental-computational approach
ASCT2 (SLC1A5) is a sodium-dependent neutral amino acid transporter that controls amino
acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates …
acid homeostasis in peripheral tissues. In cancer, ASCT2 is up-regulated where it modulates …
The concise guide to pharmacology 2013/14: transporters
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
OCTN cation transporters in health and disease: role as drug targets and assay development
The three members of the organic cation transporter novel subfamily are known to be
involved in interactions with xenobiotic compounds. These proteins are characterized by 12 …
involved in interactions with xenobiotic compounds. These proteins are characterized by 12 …