Almost three decades after the discovery of protein kinase C (PKC), we still have only a
partial understanding of how this family of serine/threonine kinases is involved in tumour …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

Rac GTPases, small G-proteins widely implicated in tumorigenesis and metastasis,
transduce signals from tyrosine-kinase, G-protein-coupled receptors (GPCRs), and integrins …

Few kinases have been studied as extensively as protein kinase C (PKC), particularly in the
context of cancer. As major cellular targets for the phorbol ester tumor promoters and …

The protein kinase C (PKC) family represents a large group of phospholipid dependent
enzymes catalyzing the covalent transfer of phosphate from ATP to serine and threonine …

Neuronal network formation in the develo** nervous system is dependent on the accurate
navigation of nerve cell axons and dendrites, which is controlled by attractive and repulsive …

Rac1 is a small GTPase that belongs to the Rho family. The Rho family of small GTPases is
a subfamily of the Ras superfamily. The Rho family of GTPases mediate a plethora of …

The assembly of neuronal networks during development requires tightly controlled cell-cell
interactions. Multiple cell surface receptors that control axon guidance and synapse …

Epidermal growth factor (EGF) receptor-mediated cell migration plays a vital role in invasion
of many tumor types. EGF receptor ligands increase invasiveness in vivo, but it remains …