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Immunosenescence and inflammaging in the aging process: age-related diseases or longevity?
During aging the immune system (IS) undergoes remarkable changes that collectively are
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
known as immunosenescence. It is a multifactorial and dynamic phenomenon that affects …
Immunology of aging: the birth of inflammaging
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
evolutionary or rather a revolutionary conceptualization of the immune changes in response …
Immunosenescence, aging and successful aging
Y Wang, C Dong, Y Han, Z Gu, C Sun - Frontiers in immunology, 2022 - frontiersin.org
Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …
playing important roles in many age-related diseases, especially neurodegenerative …
An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory
The common view is that T lymphocytes activate telomerase to delay senescence. Here we
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …
show that some T cells (primarily naïve and central memory cells) elongated telomeres by …
Immunosenescence: a key player in cancer development
J Lian, Y Yue, W Yu, Y Zhang - Journal of hematology & oncology, 2020 - Springer
Immunosenescence is a process of immune dysfunction that occurs with age and includes
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …
remodeling of lymphoid organs, leading to changes in the immune function of the elderly …
Long COVID following mild SARS-CoV-2 infection: characteristic T cell alterations and response to antihistamines
P Glynne, N Tahmasebi, V Gant… - Journal of Investigative …, 2022 - journals.sagepub.com
Long COVID is characterized by the emergence of multiple debilitating symptoms following
SARS-CoV-2 infection. Its etiology is unclear and it often follows a mild acute illness …
SARS-CoV-2 infection. Its etiology is unclear and it often follows a mild acute illness …
Human T cell development, localization, and function throughout life
Throughout life, T cells coordinate multiple aspects of adaptive immunity, including
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …
responses to pathogens, allergens, and tumors. In mouse models, the role of T cells is …
T cells genetically modified to express an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of poor-prognosis relapsed multiple myeloma
JN Brudno, I Maric, SD Hartman, JJ Rose… - Journal of Clinical …, 2018 - ascopubs.org
Purpose Therapies with novel mechanisms of action are needed for multiple myeloma (MM).
T cells can be genetically modified to express chimeric antigen receptors (CARs), which are …
T cells can be genetically modified to express chimeric antigen receptors (CARs), which are …
Immunosenescence and inflamm-aging as two sides of the same coin: friends or foes?
The immune system is the most important protective physiological system of the organism. It
has many connections with other systems and is, in fact, often considered as part of the …
has many connections with other systems and is, in fact, often considered as part of the …
The integration of inflammaging in age-related diseases
Aging is characterized by a morpho-functional adaptation, variably affecting major
physiological systems, depending on a complex interaction between genetic, environmental …
physiological systems, depending on a complex interaction between genetic, environmental …