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Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites. Compared
with normal tissue, the tumour microenvironment has some unique properties, such as …
with normal tissue, the tumour microenvironment has some unique properties, such as …
Smart nanoplatforms responding to the tumor microenvironment for precise drug delivery in cancer therapy
Y Wang, T Deng, X Liu, X Fang, Y Mo… - International Journal …, 2024 - Taylor & Francis
The tumor microenvironment (TME) is a complex and dynamic entity, comprising stromal
cells, immune cells, blood vessels and extracellular matrix, which is intimately associated …
cells, immune cells, blood vessels and extracellular matrix, which is intimately associated …
Matrix metalloproteinase-responsive drug delivery systems
C Zhang, G Jiang, X Gao - Bioconjugate chemistry, 2023 - ACS Publications
Matrix metalloproteinases (MMPs) are a class of endopeptidases that are dependent on zinc
and facilitate the degradation of extracellular matrix (ECM) proteins, thereby playing pivotal …
and facilitate the degradation of extracellular matrix (ECM) proteins, thereby playing pivotal …
Light‐guiding biomaterials for biomedical applications
Optical techniques used in medical diagnosis, surgery, and therapy require efficient and
flexible delivery of light from light sources to target tissues. While this need is currently …
flexible delivery of light from light sources to target tissues. While this need is currently …
Prognostic and immunological roles of MMP‐9 in Pan‐cancer
Y Zeng, M Gao, D Lin, G Du… - BioMed Research …, 2022 - Wiley Online Library
Background. Matrix metalloproteinase‐9 (MMP‐9) can degrade the extracellular matrix and
participate in tumor progression. The relationship between MMP‐9 and immune cells has …
participate in tumor progression. The relationship between MMP‐9 and immune cells has …
[HTML][HTML] Nanomedicine in pancreatic cancer: current status and future opportunities for overcoming therapy resistance
MK Greene, MC Johnston, CJ Scott - Cancers, 2021 - mdpi.com
Simple Summary Despite access to a vast arsenal of anticancer agents, many fail to realise
their full therapeutic potential in clinical practice. One key determinant of this is the evolution …
their full therapeutic potential in clinical practice. One key determinant of this is the evolution …
Protease specificity: towards in vivo imaging applications and biomarker discovery
Proteases are considered of major importance in biomedical research because of their
crucial roles in health and disease. Their ability to hydrolyze their protein and peptide …
crucial roles in health and disease. Their ability to hydrolyze their protein and peptide …
Stimulus-responsive nanoscale delivery systems triggered by the enzymes in the tumor microenvironment
ZT Zhang, MY Huang-Fu, WH Xu, M Han - European Journal of …, 2019 - Elsevier
The tumor microenvironment is the cellular environment that is also described as the “soil”
for supporting tumor growth, proliferation, invasion and metastasis, as well as protecting …
for supporting tumor growth, proliferation, invasion and metastasis, as well as protecting …
Cucurbit [8] uril-based supramolecular theranostics
D Wu, J Wang, X Du, Y Cao, K **, D Liu - Journal of Nanobiotechnology, 2024 - Springer
Different from most of the conventional platforms with dissatisfactory theranostic capabilities,
supramolecular nanotheranostic systems have unparalleled advantages via the artful …
supramolecular nanotheranostic systems have unparalleled advantages via the artful …
Use of stimulatory responsive soft nanoparticles for intracellular drug delivery
Drug delivery has made tremendous advances in the last decade. Targeted therapies are
increasingly common, with intracellular delivery highly impactful and sought after …
increasingly common, with intracellular delivery highly impactful and sought after …