NMR metabolomics methods for investigating disease

GA Nagana Gowda, D Raftery - Analytical chemistry, 2023 - ACS Publications
The field of metabolomics continues to grow exponentially as it contributes significantly to
numerous disciplines, including biomedicine, pharmacology, drug development, and …

Fingerprinting and profiling in metabolomics of biosamples

V Ghini, G Meoni, A Vignoli, F Di Cesare… - Progress in Nuclear …, 2023 - Elsevier
This review focuses on metabolomics from an NMR point of view. It attempts to cover the
broad scope of metabolomics and describes the NMR experiments that are most suitable for …

Metabolomics study of COVID-19 patients in four different clinical stages

A Valdés, LO Moreno, SR Rello, A Orduña… - Scientific reports, 2022 - nature.com
Abstract SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the coronavirus
strain causing the respiratory pandemic COVID-19 (coronavirus disease 2019). To …

Incomplete systemic recovery and metabolic phenoreversion in post-acute-phase nonhospitalized COVID-19 patients: implications for assessment of post-acute …

E Holmes, J Wist, R Masuda, S Lodge… - Journal of proteome …, 2021 - ACS Publications
We present a multivariate metaboty** approach to assess the functional recovery of
nonhospitalized COVID-19 patients and the possible biochemical sequelae of “Post-Acute …

Systemic perturbations in amine and kynurenine metabolism associated with acute SARS-CoV-2 infection and inflammatory cytokine responses

NG Lawler, N Gray, T Kimhofer… - Journal of Proteome …, 2021 - ACS Publications
We performed quantitative metabolic phenoty** of blood plasma in parallel with
cytokine/chemokine analysis from participants who were either SARS-CoV-2 (+)(n= 10) or …

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

S Makaremi, A Asgarzadeh, H Kianfar… - Inflammation …, 2022 - Springer
A global pandemic has erupted as a result of the new brand coronavirus, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated …

Profiling metabolites and lipoproteins in COMETA, an Italian cohort of COVID-19 patients

V Ghini, G Meoni, L Pelagatti, T Celli… - PLoS …, 2022 - journals.plos.org
Metabolomics and lipidomics have been used in several studies to define the biochemical
alterations induced by COVID-19 in comparison with healthy controls. Those studies …

1H qNMR-Based Metabolomics Discrimination of Covid-19 Severity

BSB Correia, VG Ferreira, PMFD Piagge… - Journal of Proteome …, 2022 - ACS Publications
The coronavirus disease 2019 (Covid-19), which caused respiratory problems in many
patients worldwide, led to more than 5 million deaths by the end of 2021. Experienced …

Integrative modeling of plasma metabolic and lipoprotein biomarkers of SARS-CoV-2 infection in Spanish and Australian COVID-19 patient cohorts

R Masuda, S Lodge, P Nitschke, M Spraul… - Journal of proteome …, 2021 - ACS Publications
Quantitative plasma lipoprotein and metabolite profiles were measured on an autonomous
community of the Basque Country (Spain) cohort consisting of hospitalized COVID-19 …

COVID-19: A complex disease with a unique metabolic signature

V Ghini, W Vieri, T Celli, V Pecchioli, N Boccia… - PLoS …, 2023 - journals.plos.org
Plasma of COVID-19 patients contains a strong metabolomic/lipoproteomic signature,
revealed by the NMR analysis of a cohort of> 500 patients sampled during various waves of …