Vascular contributions to Alzheimer's disease

LB Eisenmenger, A Peret, BM Famakin, A Spahic… - Translational …, 2023 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Pathological changes within the cerebral vasculature in Alzheimer's disease: New perspectives

RA Fisher, JS Miners, S Love - Brain Pathology, 2022 - Wiley Online Library
Cerebrovascular disease underpins vascular dementia (VaD), but structural and functional
changes to the cerebral vasculature contribute to disease pathology and cognitive decline in …

Impaired glymphatic system as evidenced by low diffusivity along perivascular spaces is associated with cerebral small vessel disease: a population-based study

Y Tian, X Cai, Y Zhou, A **, S Wang, Y Yang… - Stroke and Vascular …, 2023 - svn.bmj.com
Objective This study aims to investigate the associations of glymphatic system with the
presence, severity and neuroimaging phenotypes of cerebral small vessel disease (CSVD) …

Age-related loss of Notch3 underlies brain vascular contractility deficiencies, glymphatic dysfunction, and neurodegeneration in mice

MC Romay, RH Knutsen, F Ma… - The Journal of …, 2024 - Am Soc Clin Investig
Vascular aging affects multiple organ systems, including the brain, where it can lead to
vascular dementia. However, a concrete understanding of how aging specifically affects the …

Cerebral small vessel disease pathology in COVID-19 patients: A systematic review

CD Owens, CB Pinto, S Detwiler, P Mukli… - Ageing Research …, 2023 - Elsevier
Cerebral small vessel disease (CSVD) is the leading cause of vascular cognitive impairment
and is associated with COVID-19. However, contributing factors that often accompany CSVD …

The underlying role of the glymphatic system and meningeal lymphatic vessels in cerebral small vessel disease

Y Tian, M Zhao, Y Chen, M Yang, Y Wang - Biomolecules, 2022 - mdpi.com
There is a growing prevalence of vascular cognitive impairment (VCI) worldwide, and most
research has suggested that cerebral small vessel disease (CSVD) is the main contributor to …

Model-based whole-brain perturbational landscape of neurodegenerative diseases

YS Perl, S Fittipaldi, CG Campo, S Moguilner, J Cruzat… - Elife, 2023 - elifesciences.org
The treatment of neurodegenerative diseases is hindered by lack of interventions capable of
steering multimodal whole-brain dynamics towards patterns indicative of preserved brain …

Association of cerebral small vessel disease with gait and balance disorders

C Su, X Yang, S Wei, R Zhao - Frontiers in aging neuroscience, 2022 - frontiersin.org
Cerebral small vessel disease (CSVD) is a common cerebrovascular disease and an
important cause of gait and balance disorders. Gait and balance disorders can further lead …

Microangiopathy in temporal lobe epilepsy with diffusion MRI alterations and cognitive decline

J Liu, L Binding, I Puntambekar, S Patodia, YM Lim… - Acta …, 2024 - Springer
White matter microvascular alterations in temporal lobe epilepsy (TLE) may be relevant to
acquired neurodegenerative processes and cognitive impairments associated with this …

Functional connectivity changes in cerebral small vessel disease-a systematic review of the resting-state MRI literature

M Schulz, C Malherbe, B Cheng, G Thomalla… - BMC medicine, 2021 - Springer
Background Cerebral small vessel disease (CSVD) is a common neurological disease
present in the ageing population that is associated with an increased risk of dementia and …