Gene-specific transcription factors (TFs) are key regulatory components of signaling
pathways, controlling, for example, cell growth, development, and stress responses. Their …

Bacteria have evolved sophisticated mechanisms for regulation of metabolic pathways.
Such regulatory circuits ensure that anabolic pathways remain repressed unless final …

The capacity of cells and organisms to respond to challenging conditions in a repeatable
manner is limited by a finite repertoire of pre-evolved adaptive responses. Beyond this …

Highlights•Transcription factor specificity is dictated by a complex set of mechanisms.•
Simplistic models of DNA binding do not predict observed behaviour.•Recent experimental …

Abstract Proteins containing PER-ARNT-SIM (PAS) domains are commonly associated with
environmental adaptation in a variety of organisms. The PAS domain is found in proteins …

In a process known as facilitated diffusion, DNA-binding proteins find their target sites by
combining three-dimensional diffusion and one-dimensional scanning of the DNA …

Metazoans encode clusters of paralogous Hox genes that are critical for proper
development of the body plan. However, there are a number of unresolved issues regarding …

The transcription factor ICP4 from herpes simplex virus has a central role in regulating the
gene expression cascade which controls viral infection. Here we present the crystal structure …

Proteins are highly dynamic entities. Their myriad functions require specific structures, but
proteins' dynamic nature ranges all the way from the local mobility of their amino acid …

Interrupted dimeric coiled coil segments are found in a broad range of proteins and
generally confer selective functional properties such as binding to specific ligands. However …