Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most
frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth …

Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is a non-receptor protein
tyrosine phosphatase ubiquitously expressed mainly in the cytoplasm of several tissues …

JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

Abstract Interleukin-6 (IL-6) is a major cytokine that promotes anti-and pro-inflammatory
outcomes by activating the membrane IL-6 receptor (IL-6R) or the soluble IL-6 receptor (sIL …

The host stimulator of interferon genes (STING) signaling pathway is a major innate immune
sensing pathway, and the stimulation of this pathway within antigen-presenting cells shows …

Macrophages are heterogeneous cells that can be polarized into M1 or M2 phenotype. m6A
“reader” YTH domain family protein 2 (YTHDF2) has been the m6A binding protein with the …

Systemic sclerosis and systemic lupus erythematosus represent two distinct autoimmune
diseases belonging to the group of connective tissue disorders. Despite the great progress …

Introduction Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a
ubiquitously expressed, non-receptor protein tyrosine phosphatase encoded by the PTPN11 …

Facet joint osteoarthritis (FJOA), a condition commonly observed in individuals of middle to
old age, has been relatively under-researched compared to other subtypes of osteoarthritis …

Traumatic brain injury (TBI) is a common and often devastating illness, with wide-ranging
public health implications. In addition to the primary injury, victims of TBI are at risk for …