Machine and deep learning for longitudinal biomedical data: a review of methods and applications

A Cascarano, J Mur-Petit… - Artificial Intelligence …, 2023 - Springer
Exploiting existing longitudinal data cohorts can bring enormous benefits to the medical
field, as many diseases have a complex and multi-factorial time-course, and start to develop …

Predictive models for health deterioration: Understanding disease pathways for personalized medicine

BM Eskofier, J Klucken - Annual Review of Biomedical …, 2023 - annualreviews.org
Artificial intelligence (AI) and machine learning (ML) methods are currently widely employed
in medicine and healthcare. A PubMed search returns more than 100,000 articles on these …

Predicting the impact of treatments over time with uncertainty aware neural differential equations.

E De Brouwer, J Gonzalez… - … Conference on Artificial …, 2022 - proceedings.mlr.press
Predicting the impact of treatments from ob-servational data only still represents a major
challenge despite recent significant advances in time series modeling. Treatment …

Early diagnosis of multiple sclerosis using swept-source optical coherence tomography and convolutional neural networks trained with data augmentation

A López-Dorado, M Ortiz, M Satue, MJ Rodrigo… - Sensors, 2021 - mdpi.com
Background: The aim of this paper is to implement a system to facilitate the diagnosis of
multiple sclerosis (MS) in its initial stages. It does so using a convolutional neural network …

Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis

V Fuh-Ngwa, Y Zhou, PE Melton, I van der Mei… - Scientific Reports, 2022 - nature.com
Limited studies have been conducted to identify and validate multiple sclerosis (MS) genetic
loci associated with disability progression. We aimed to identify MS genetic loci associated …

Combining clinical and genetic data to predict response to fingolimod treatment in relapsing remitting multiple sclerosis patients: a precision medicine approach

L Ferrè, F Clarelli, B Pignolet, E Mascia… - Journal of Personalized …, 2023 - mdpi.com
A personalized approach is strongly advocated for treatment selection in Multiple Sclerosis
patients due to the high number of available drugs. Machine learning methods proved to be …

Explainable machine learning on baseline MRI predicts multiple sclerosis trajectory descriptors

S Campanioni, C Veiga, JM Prieto-González… - Plos one, 2024 - journals.plos.org
Multiple sclerosis (MS) is a multifaceted neurological condition characterized by challenges
in timely diagnosis and personalized patient management. The application of Artificial …

Retrospective cohort study to devise a treatment decision score predicting adverse 24-month radiological activity in early multiple sclerosis

A Hapfelmeier, BI On, M Mühlau… - Therapeutic …, 2023 - journals.sagepub.com
Background: Multiple sclerosis (MS) is a chronic neuroinflammatory disease affecting about
2.8 million people worldwide. Disease course after the most common diagnoses of relapsing …

Validation of a machine learning approach to estimate expanded disability status scale scores for multiple sclerosis

P Alves, E Green, M Leavy, H Friedler… - Multiple Sclerosis …, 2022 - journals.sagepub.com
Background Disability assessment using the Expanded Disability Status Scale (EDSS) is
important to inform treatment decisions and monitor the progression of multiple sclerosis …

Learning spatio-temporal model of disease progression with NeuralODEs from longitudinal volumetric data

D Lachinov, A Chakravarty, C Grechenig… - … on Medical Imaging, 2023 - ieeexplore.ieee.org
Robust forecasting of the future anatomical changes inflicted by an ongoing disease is an
extremely challenging task that is out of grasp even for experienced healthcare …