Biocatalysis making waves in organic chemistry

U Hanefeld, F Hollmann, CE Paul - Chemical Society Reviews, 2022 - pubs.rsc.org
Biocatalysis has an enormous impact on chemical synthesis. The waves in which
biocatalysis has developed, and in doing so changed our perception of what organic …

Enzyme co-immobilization: Always the biocatalyst designers' choice… or not?

S Arana-Peña, D Carballares… - Biotechnology …, 2021 - Elsevier
The increasing relevance of cascade reactions in biocatalysis has sparked a great interest
for enzyme co-immobilization. Enzyme co-immobilization allows access to some kinetic …

Artificial biocatalytic linear cascades for preparation of organic molecules

JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …

The rise of continuous flow biocatalysis–fundamentals, very recent developments and future perspectives

P De Santis, LE Meyer, S Kara - Reaction Chemistry & Engineering, 2020 - pubs.rsc.org
Biocatalysis community has witnessed a drastic increase in the number of studies for the use
of enzymes in continuously operated flow reactors. This significant interest arose from the …

Round, round we go–strategies for enzymatic cofactor regeneration

S Mordhorst, JN Andexer - Natural product reports, 2020 - pubs.rsc.org
Covering: up to the beginning of 2020 Enzymes depending on cofactors are essential in
many biosynthetic pathways of natural products. They are often involved in key steps …

Transaminase biocatalysis: optimization and application

F Guo, P Berglund - Green Chemistry, 2017 - pubs.rsc.org
Transaminases (TAs) are one of the most promising biocatalysts in organic synthesis for the
preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity …

Cofactor NAD (P) H regeneration inspired by heterogeneous pathways

X Wang, T Saba, HHP Yiu, RF Howe, JA Anderson… - Chem, 2017 - cell.com
Biocatalysis can empower chemical, pharmaceutical, and energy industries, where the use
of enzymes facilitates low-energy, sustainable methods of producing high-value chemicals …

Enzyme immobilization in hydrogels: A perfect liaison for efficient and sustainable biocatalysis

J Meyer, LE Meyer, S Kara - Engineering in Life Sciences, 2022 - Wiley Online Library
Biocatalysis is an established chemical synthesis technology that has by no means been
restricted to research laboratories. The use of enzymes for organic synthesis has evolved …

Biocatalytic imine reduction and reductive amination of ketones

JH Schrittwieser, S Velikogne… - Advanced Synthesis & …, 2015 - Wiley Online Library
Chiral amines represent a prominent functional group in pharmaceuticals and
agrochemicals and are hence attractive targets for asymmetric synthesis. Since the …

The industrial age of biocatalytic transamination

M Fuchs, JE Farnberger… - European Journal of …, 2015 - Wiley Online Library
During the last decade the use of ω‐transaminases has been identified as a very powerful
method for the preparation of optically pure amines from the corresponding ketones. Their …