Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) proteins in the
interstitium. It is an essential pathological response to chronic inflammation. ECM protein …

The extracellular matrix (ECM) is an essential component of the heart that imparts
fundamental cellular processes during organ development and homeostasis. Most …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple
cardiac cell lineages during embryonic development and provides signals that are essential …

Heart development is a continuous process involving significant remodeling during
embryogenesis and neonatal stages. To date, several groups have used single-cell …

To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular
development, we generated single-cell chromatin accessibility maps of human fetal heart …

The adult mammalian heart has limited capacity for regeneration following injury, whereas
the neonatal heart can readily regenerate within a short period after birth. Neonatal heart …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

This 8th Edition of Moss and Adams' Heart Disease in Infants, Children, and Adolescents:
Including the Fetus and Young Adult, provides updated and useful information from leading …

Aims Epicardium and epicardium-derived cells are critical players in myocardial fibrosis.
Mesenchymal stem cell–derived extracellular vesicles (EVs) have been studied for cardiac …