On the Power and Challenges of Atomistic Molecular Dynamics to Investigate RNA Molecules

S Muscat, G Martino, J Manigrasso… - Journal of Chemical …, 2024 - ACS Publications
RNA molecules play a vital role in biological processes within the cell, with significant
implications for science and medicine. Notably, the biological functions exerted by specific …

Advances, Applications, and Perspectives in Small‐Angle X‐ray Scattering of RNA

JN Tants, A Schlundt - Chembiochem, 2023 - Wiley Online Library
RNAs exhibit a plethora of functions far beyond transmitting genetic information. Often, RNA
functions are entailed in their structure, be it as a regulatory switch, protein binding site, or …

RNA structures and dynamics with Å resolution revealed by x-ray free-electron lasers

KA Zielinski, S Sui, SA Pabit, DA Rivera, T Wang… - Science …, 2023 - science.org
RNA macromolecules, like proteins, fold to assume shapes that are intimately connected to
their broadly recognized biological functions; however, because of their high charge and …

Biophysical characterisation of human LincRNA-p21 sense and antisense Alu inverted repeats

MH D'Souza, T Mrozowich, MD Badmalia… - Nucleic acids …, 2022 - academic.oup.com
Abstract Human Long Intergenic Noncoding RNA-p21 (LincRNA-p21) is a regulatory
noncoding RNA that plays an important role in promoting apoptosis. LincRNA-p21 is also …

Structural analyses of an RNA stability element interacting with poly (A)

SF Torabi, YL Chen, K Zhang, J Wang… - Proceedings of the …, 2021 - National Acad Sciences
Cis-acting RNA elements are crucial for the regulation of polyadenylated RNA stability. The
element for nuclear expression (ENE) contains a U-rich internal loop flanked by short …

Modeling, simulations, and bioinformatics at the service of RNA structure

PD Dans, D Gallego, A Balaceanu, L Darré, H Gómez… - Chem, 2019 - cell.com
Although chemically close to DNA, RNA can adopt a wide range of structures from regular
helices to complex globular conformations, showing a complexity similar to that of proteins …

Comparing state-of-the-art approaches to back-calculate SAXS spectra from atomistic molecular dynamics simulations

M Bernetti, G Bussi - The European Physical Journal B, 2021 - Springer
Small-angle X-ray scattering (SAXS) experiments are arising as an effective instrument in
the structural characterization of biomolecules in solution. However, they suffer from limited …

RETRACTED: Application of the small-angle X-ray scattering technique for structural analysis studies: A review

J Li, A Jiao, S Chen, Z Wu, E Xu, Z ** - 2018 - Elsevier
This article (and corrigendum) has been found to contain data which were reported citing
improper references so that the reproducibility of the experiments and the interpretation of …

Structure of the RNA specialized translation initiation element that recruits eIF3 to the 5′-UTR of c-Jun

MJ Walker, MD Shortridge, DD Albin… - Journal of molecular …, 2020 - Elsevier
Specialized translation initiation is a novel form of regulation of protein synthesis, whereby
RNA structures within the 5′-UTR regulate translation rates of specific mRNAs. Similar to …

Selective deuteration of an RNA: RNA complex for structural analysis using small-angle scattering

A Munsayac, WC Leite, JB Hopkins, I Hall, HM O'Neill… - Structure, 2025 - cell.com
The structures of RNA: RNA complexes regulate many biological processes. Despite their
importance, protein-free RNA: RNA complexes represent a tiny fraction of experimentally …