Atomic force microscopy as a tool for assessing the cellular elasticity and adhesiveness to identify cancer cells and tissues
From the first experiments of the atomic force microscopy (AFM) with biological samples, the
range of its potential applications grows extensively. One of them is the use of AFM to …
range of its potential applications grows extensively. One of them is the use of AFM to …
Atomic force microscopy for revealing micro/nanoscale mechanics in tumor metastasis: from single cells to microenvironmental cues
Mechanics are intrinsic properties which appears throughout the formation, development,
and aging processes of biological systems. Mechanics have been shown to play important …
and aging processes of biological systems. Mechanics have been shown to play important …
Glycocalyx regulates the strength and kinetics of cancer cell adhesion revealed by biophysical models based on high resolution label-free optical data
The glycocalyx is thought to perform a potent, but not yet defined function in cellular
adhesion and signaling. Since 95% of cancer cells have altered glycocalyx structure, this …
adhesion and signaling. Since 95% of cancer cells have altered glycocalyx structure, this …
Using adhesive micropatterns and AFM to assess cancer cell morphology and mechanics
The mechanical properties of living cells reflect their physiological and pathological state. In
particular, cancer cells undergo cytoskeletal modifications that typically make them softer …
particular, cancer cells undergo cytoskeletal modifications that typically make them softer …
Atomic force microscopy in characterizing cell mechanics for biomedical applications: A review
Cell mechanics is a novel label-free biomarker for indicating cell states and pathological
changes. The advent of atomic force microscopy (AFM) provides a powerful tool for …
changes. The advent of atomic force microscopy (AFM) provides a powerful tool for …
Advances in atomic force microscopy for single-cell analysis
Single-cell analysis has been considered as a promising way to uncover the underlying
mechanisms guiding the mysteries of life activities, which considerably complements …
mechanisms guiding the mysteries of life activities, which considerably complements …
Circulating tumor cells in cancer diagnostics and prognostics by single-molecule and single-cell characterization
Circulating tumor cells (CTCs) represent an interesting source of biomarkers for diagnosis,
prognosis, and the prediction of cancer recurrence, yet while they are extensively studied in …
prognosis, and the prediction of cancer recurrence, yet while they are extensively studied in …
Automated high-throughput atomic force microscopy single-cell nanomechanical assay enabled by deep learning-based optical image recognition
R **ao, Y Zhang, M Li - Nano Letters, 2024 - ACS Publications
Mechanical forces are essential for life activities, and the mechanical phenotypes of single
cells are increasingly gaining attention. Atomic force microscopy (AFM) has been a standard …
cells are increasingly gaining attention. Atomic force microscopy (AFM) has been a standard …
[HTML][HTML] Substrate stiffness modulates the viscoelastic properties of MCF-7 cells
JC Gil-Redondo, A Weber, B Zbiral… - Journal of the …, 2022 - Elsevier
Cells sense stiffness of surrounding tissues and adapt their activity, proliferation, motility and
mechanical properties based on such interactions. Cells probe the stiffness of the substrate …
mechanical properties based on such interactions. Cells probe the stiffness of the substrate …
Application of self-organizing maps to AFM-based viscoelastic characterization of breast cancer cell mechanics
Cell mechanical properties have been proposed as label free markers for diagnostic
purposes in diseases such as cancer. Cancer cells show altered mechanical phenotypes …
purposes in diseases such as cancer. Cancer cells show altered mechanical phenotypes …