The catalysis by primary and secondary amines of electrophilic substitution reactions in the
R-position of carbonyl compounds and related reactions via enamine intermediates is called …

Asymmetric aldol reactions are a powerful method for the construction of carbon–carbon
bonds in an enantioselective fashion. Historically this reaction has been performed in a …

The enantioselective production of compounds is a central theme in current research. The
broad utility of synthetic chiral molecules as single-enantiomer pharmaceuticals, in …

We have developed direct asymmetric cross-aldol reactions that can be performed in water
without addition of organic solvents. A bifunctional catalyst with a long hydrophobic alkyl …

Abstract (Figure Presented) What expression best conveys the recent examples of"
aqueous" organocatalyzed aldol reactions? It is suggested that a reaction occurs" in water" if …

In the area of asymmetric organocatalysis, significant effort has been dedicated during the
last decade to improve the performance of emblematic catalysts such as proline, as well as …

The use of simple (S)-proline as catalyst for the intermolecular direct aldol reaction at the
beginning of this century became a true milestone in the growth of organocatalysis as a …

In water , on water , and by water : mimicking nature's aldolases with organocatalysis and water -
Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C004970K Royal Society of …

Wet and wild: Water is a powerful force in nature, as evident in the painting “ES” by Zdzislaw
Beksinski (1985, oil, 92 cm× 90 cm; reproduced with permission from Piotr Dmochowski), as …

In nature there are at least nineteen different acyclic amino acids that act as the building
blocks of polypeptides and proteins with different functions. Here we report that α‐amino …