Effective responses against severe systemic infection require coordination between two
complementary defense strategies that minimize the negative impact of infection on the host …

Bloodstream infections (BSIs) are common in hospitals, often life-threatening and increasing
in prevalence. Microorganisms in the blood are usually rapidly cleared by the immune …

Neutrophils are critical in the host defense against Staphylococcus aureus, a major human
pathogen. However, even in the setting of a robust neutrophil response, S. aureus can …

Type VI secretion systems (T6SS), recently described in hypervirulent K. pneumoniae (hvKp)
strains, are involved in bacterial warfare but their role in classical clinical strains (cKp) has …

Melatonin has various physiological effects, such as the maintenance of circadian rhythms,
anti-inflammatory functions, and regulation of intestinal barriers. The regulatory functions of …

Background: Staphylococcus aureus (S. aureus) is a common cause of hospital-and
community-acquired infections that can result in various clinical manifestations ranging from …

Gram-negative bacteremia is a major cause of global morbidity involving three phases of
pathogenesis: initial site infection, dissemination, and survival in the blood and filtering …

Neuroinflammation and oxidative stress damage are involved in the pathogenesis of
cerebral ischemia–reperfusion injury (CIRI). Ferroptosis emerged as a new player in the …

Background The gut microbiota is a complex microbial community that changes in response
to various intestinal diseases, including aging-related diseases such as sarcopenia. Several …

Bacteremia, a leading cause of death, generally arises after bacteria establish infection in a
particular tissue and transit to secondary sites. Studying dissemination from primary sites by …