Pancreatic cancer is a highly deadly disease: almost all patients develop metastases and
conventional treatments have little impact on survival. Therapeutically, this tumor is poorly …

Diabetes mellitus (DM), one of the most common life-threatening illnesses worldwide, is a
group of metabolic diseases, characterized by sustained hyperglycemia. The global …

Here, we propose a new strategy for the treatment of early cancerous lesions and advanced
metastatic disease, via the selective targeting of cancer stem cells (CSCs), aka, tumor …

Cancer stem cells (CSCs) represent a subpopulation of tumor cells that possess self‐
renewal and tumor initiation capacity and the ability to give rise to the heterogenous …

The current view is that breast cancer is a stem cell disease characterized by the existence
of cancer cells with stem-like features and tumor-initiating potential. These cells are made …

Metformin is a standard clinical drug used to treat type 2 diabetes mellitus (T2DM) and
polycystic ovary syndrome. Recently, epidemiological studies and meta‑analyses have …

BACKGROUND: Diabetes mellitus is associated with an increased incidence of colorectal
cancer, but the impact of diabetes mellitus on colorectal cancer prognosis is not clear …

Cancer stem cell theory postulates that a small population of tumor-initiating cells is
responsible for the development, progression and recurrence of several malignancies …

Despite marked tumor shrinkage after 5-FU treatment, the frequency of colon cancer relapse
indicates that a fraction of tumor cells survives treatment causing tumor recurrence. The …

Both diabetes mellitus and cancer are prevalent diseases worldwide. It is evident that there
is a substantial increase in cancer incidence in diabetic patients. Epidemiologic studies …