Puberty marks the end of childhood and is a period when individuals undergo physiological
and psychological changes to achieve sexual maturation and fertility. The hypothalamic …

For 50 years the term 'gene'has been synonymous with regions of the genome encoding
mRNAs that are translated into protein. However, recent genome‐wide studies have shown …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Abstract Background Mendelian Randomization (MR) studies assess the causality of an
exposure–disease association using genetic determinants [ie instrumental variables (IVs)] of …

The timing of puberty is a highly polygenic childhood trait that is epidemiologically
associated with various adult diseases. Using 1000 Genomes Project–imputed genotype …

Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

MicroRNAs (miRNAs) are key regulators of gene expression. They are conserved across
species, expressed across cell types, and active against a large proportion of the …

Menarche is a milestone in a woman's life as it denotes the start of reproductive capacity.
Aim of this report is to review the recent developments and the current knowledge in the …

Regeneration capacity declines with age, but why juvenile organisms show enhanced tissue
repair remains unexplained. Lin28a, a highly conserved RNA-binding protein expressed …

LIN28B regulates developmental processes by modulating microRNAs (miRNAs) of the let-7
family. A role for LIN28B in cancer has been proposed but has not been established in vivo …