A narrative review on plasminogen activator inhibitor-1 and its (patho) physiological role: to target or not to target?

M Sillen, PJ Declerck - International journal of molecular sciences, 2021 - mdpi.com
Plasminogen activator inhibitor-1 (PAI-1) is the main physiological inhibitor of plasminogen
activators (PAs) and is therefore an important inhibitor of the plasminogen/plasmin system …

Choroid plexus pathophysiology

Y Courtney, A Hochstetler… - Annual Review of …, 2024 - annualreviews.org
This review examines the crucial roles of the choroid plexus (ChP) in central nervous system
(CNS) pathology, emphasizing its involvement in disease mechanisms and therapeutic …

[HTML][HTML] Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium

F Jacob, SR Pather, WK Huang, F Zhang, SZH Wong… - Cell stem cell, 2020 - cell.com
Neurological complications are common in patients with COVID-19. Although severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal pathogen of COVID-19, has …

Choroid plexus enlargement in inflammatory multiple sclerosis: 3.0-T MRI and translocator protein PET evaluation

VAG Ricigliano, E Morena, A Colombi, M Tonietto… - Radiology, 2021 - pubs.rsna.org
Background Choroid plexuses (CPs) have been suggested as a key gateway for
inflammation in experimental autoimmune encephalitis, but in vivo evidence of their …

Multiple sclerosis: inflammatory and neuroglial aspects

G Papiri, G D'Andreamatteo, G Cacchiò, S Alia… - Current Issues in …, 2023 - mdpi.com
Multiple sclerosis (MS) represents the most common acquired demyelinating disorder of the
central nervous system (CNS). Its pathogenesis, in parallel with the well-established role of …

Choroid plexus volume in multiple sclerosis predicts expansion of chronic lesions and brain atrophy

S Klistorner, MH Barnett, J Parratt… - Annals of clinical …, 2022 - Wiley Online Library
Objectives Recent studies suggested that the expansion of long‐standing multiple sclerosis
(MS) lesions and an enlargement of choroid plexus may be linked to chronic inflammation …

Deconstructing the functional neuroanatomy of the choroid plexus: an ontogenetic perspective for studying neurodevelopmental and neuropsychiatric disorders

BKY Bitanihirwe, P Lizano, TUW Woo - Molecular Psychiatry, 2022 - nature.com
The choroid plexus (CP) is a delicate and highly vascularized structure in the brain
comprised of a dense network of fenestrated capillary loops that help in the synthesis …

Oncostatin M triggers brain inflammation by compromising blood–brain barrier integrity

D Hermans, E Houben, P Baeten, H Slaets… - Acta …, 2022 - Springer
Oncostatin M (OSM) is an IL-6 family member which exerts neuroprotective and
remyelination-promoting effects after damage to the central nervous system (CNS) …

Choroid plexus function in neurological homeostasis and disorders: The awakening of the circadian clocks and orexins

J Christensen, C Li… - Journal of Cerebral Blood …, 2022 - journals.sagepub.com
As research regarding the role of circadian rhythms, sleep, and the orexinergic system in
neurodegenerative diseases is growing, it is surprising that the choroid plexus (CP) remains …

Enlarged choroid plexus related to iron rim lesions and deep gray matter atrophy in relapsing-remitting multiple sclerosis

X Wang, Q Zhu, Z Yan, Z Shi, Y Xu, Y Liu, Y Li - Multiple Sclerosis and …, 2023 - Elsevier
Background Choroid plexus (CP) is considered to be linked to inflammation of multiple
sclerosis (MS), but its connection with markers of inflammation in vivo in MS is unclear, the …