Constant remodeling of tight junctions to regulate trans-epithelial permeability is essential in
maintaining intestinal barrier functions and thus preventing diffusion of small molecules and …

Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …

Human organoids-on-chips (OrgOCs) are the synergism of human organoids (HOs)
technology and microfluidic organs-on-chips (OOCs). OOCs can mimic extrinsic …

The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

In the last decade, organoid research has entered a golden era, signifying a pivotal shift in
the biomedical landscape. The year 2023 marked a milestone with the publication of …

Over the past years, several preclinical in vitro and ex vivo models have been developed
that helped to understand some of the critical aspects of intestinal functions in health and …

The intestine contains the largest microbial community in the human body, the gut
microbiome. Increasing evidence suggests that it plays a crucial role in maintaining overall …

In vitro models of the human gut help compensate for the limitations of animal models in
studying the human gut–microbiota interaction and are indispensable in the clarification the …

The intestinal epithelium has one of the highest turnover rates in the human body, which is
supported by intestinal stem cells. Culture models of intestinal physiology have been …

Human norovirus (HuNoV) is a major cause of acute gastroenteritis and foodborne
diseases, affecting all age groups. Despite its clinical needs, no approved antiviral therapies …