Background Cancer is the most prevalent cause of death globally, and radiotherapy is
considered the standard of care for most solid tumors, including lung, breast, esophageal …

Radiotherapy (RT), besides cancer cells, also affects the tumor microenvironment (TME):
tumor blood vessels and cells of the immune system. It damages endothelial cells and …

Radiotherapy (RT) is currently used in more than 50% of cancer patients during the course
of their disease in the curative, adjuvant or palliative setting. RT achieves good local control …

Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is
increasing the susceptibility of cells to death. Cancer cells have developed a capability of …

Radiotherapy (RT) has been applied for decades as a treatment modality in the
management of various types of cancer. Ionizing radiation induces tumor cell death, which in …

Purpose: No biomarker to personalize treatment in locally advanced rectal cancer (LARC) is
currently available. We assessed in LARC whether a diagnostic biopsy-adapted …

Cancer-associated fibroblasts (CAFs) are an important component of the tumor
microenvironment that are involved in multiple aspects of cancer progression and …

Radiation therapy has been used for many years to treat tumors based on its DNA-damage-
mediated ability to kill cells. More recently, RT has been shown to exert beneficial …

Immuno-oncology is an emerging field in the treatment of oncological diseases, that is
based on recruitment of the host immune system to attack the tumor. Radiation exposure …

Purpose Radiation therapy (RT) induces an immune response, but the relationship of this
response with tumor type is not fully understood. This meta-analysis further elucidated this …