Eukaryotic elongation factor 1A (eEF1A) canonically delivers amino acyl tRNA to the
ribosomal A site during the elongation stage of protein biosynthesis. Yet paradoxically, the …

Inhibiting eukaryotic protein translation with small molecules is emerging as a powerful
therapeutic strategy. The advantage of targeting cellular translational machinery is that it is …

Solid-phase total synthesis of nannocystin Ax (1) was disclosed. A coupling reaction
between a peptide and a polyketide moiety was conducted on a solid support, and …

A full account of our efforts directed toward the stereoselective total synthesis of nannocystin
A, a macrocyclic myxobacterial metabolite, is presented. In this endeavor, we have …

Natural product total synthesis is in essence target-oriented in that a set of organic
transformations are orchestrated into a workable process, leading ultimately to the target …

We have accomplished a 10-step (longest linear) total synthesis of nannocystin A on a four
hundred milligram scale. The previously reported Kobayashi vinylogous Mukaiyama aldol …

This dissertation describes my efforts for 5 unique projects. In the first study, the concept of
conformational control of cyclohexanes was applied to the synthesis of several Hoveyda …

Im ersten Teil dieser Arbeit wird eine erfolgreiche Totalsynthese von Nannocystin Ax
dargestellt. Dieses 21-gliedrige Depsipeptid wurde erstmals 2015 von Hoepfner et al …