Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - Signal transduction and …, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Macrophage plasticity: signaling pathways, tissue repair, and regeneration

L Yan, J Wang, X Cai, YC Liou, HM Shen, J Hao… - MedComm, 2024 - Wiley Online Library
Macrophages are versatile immune cells with remarkable plasticity, enabling them to adapt
to diverse tissue microenvironments and perform various functions. Traditionally categorized …

Metal–organic framework nanocomposites in conquering hypoxia for tumor therapy

S Zhou, F Jia, Y Wei, J Du, J Liu… - Advanced Functional …, 2024 - Wiley Online Library
Hypoxia, as a distinctive feature of tumors, is closely related to tumor recurrence, metastasis,
and treatment resistance. Metal–organic framework (MOF) exhibits an increasing number of …

Tumor-derived extracellular vesicles regulate macrophage polarization: role and therapeutic perspectives

L Wang, W Wang, D Hu, Y Liang, Z Liu… - Frontiers in …, 2024 - frontiersin.org
Extracellular vesicles (EVs) are important cell-to-cell communication mediators. This paper
focuses on the regulatory role of tumor-derived EVs on macrophages. It aims to investigate …

Iron‐MOFs for Biomedical Applications

Z Yu, M Lepoitevin, C Serre - Advanced Healthcare Materials, 2024 - Wiley Online Library
Over the past two decades, iron‐based metal–organic frameworks (Fe‐MOFs) have
attracted significant research interest in biomedicine due to their low toxicity, tunable …

Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

M Ashrafizadeh, AR Aref, G Sethi, YN Ertas… - The Journal of Nutritional …, 2024 - Elsevier
Macrophages are phagocytic cells with important physiological functions, including the
digestion of cellular debris, foreign substances, and microbes, as well as tissue …

Acidic environment-responsive metal organic framework-mediated dihydroartemisinin delivery for triggering production of reactive oxygen species in drug-resistant …

X Yan, X Zhao, M Fan, W Zheng, G Zhu… - International Journal of …, 2024 - Taylor & Francis
Background Dihydroartemisinin (DHA) has emerged as a promising candidate for
anticancer therapy. However, the application of DHA in clinics has been hampered by …

Dihydroartemisinin‐driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer

LG Li, J Hu, N Han, NN Chen, TT Yu… - Phytotherapy …, 2024 - Wiley Online Library
Enhancement of malignant cell immunogenicity to relieve immunosuppression of lung
cancer microenvironment is essential in lung cancer treatment. In previous study, we have …

Determining M2 macrophages content for the anti-tumor effects of metal-organic framework-encapsulated pazopanib nanoparticles in breast cancer

Z Xu, Z Zhou, X Yang, A Thakur, N Han, HT Li… - Journal of …, 2024 - Springer
Pazopanib (PAZ), an oral multi-tyrosine kinase inhibitor, demonstrates promising cytostatic
activities against various human cancers. However, its clinical utility is limited by substantial …

[HTML][HTML] Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Y Chen, Q Zhou, Z Jia, N Cheng, S Zhang… - … Pharmaceutica Sinica B, 2024 - Elsevier
Immunotherapy is an important cancer treatment method that offers hope for curing cancer
patients. While immunotherapy has achieved initial success, a major obstacle to its …