Refactoring transcription factors for metabolic engineering
C Deng, Y Wu, X Lv, J Li, Y Liu, G Du, J Chen… - Biotechnology …, 2022 - Elsevier
Due to the ability to regulate target metabolic pathways globally and dynamically, metabolic
regulation systems composed of transcription factors have been widely used in metabolic …
regulation systems composed of transcription factors have been widely used in metabolic …
Machine learning: its challenges and opportunities in plant system biology
Sequencing technologies are evolving at a rapid pace, enabling the generation of massive
amounts of data in multiple dimensions (eg, genomics, epigenomics, transcriptomic …
amounts of data in multiple dimensions (eg, genomics, epigenomics, transcriptomic …
FoodOmics as a promising strategy to study the effects of sourdough on human health and nutrition, as well as product quality and safety; back to the future
A Sadeghi, M Ebrahimi, F Ha**ia, MS Kharazmi… - Trends in Food Science …, 2023 - Elsevier
Background Investigating the correlation between sourdough (SD) as an ancient
fermentation technology and high-throughput meta-omics strategies like foodOmics is …
fermentation technology and high-throughput meta-omics strategies like foodOmics is …
Bacterial single-cell RNA sequencing captures biofilm transcriptional heterogeneity and differential responses to immune pressure
Biofilm formation is an important mechanism of survival and persistence for many bacterial
pathogens. These multicellular communities contain subpopulations of cells that display …
pathogens. These multicellular communities contain subpopulations of cells that display …
[HTML][HTML] Mechanisms and biotechnological applications of transcription factors
H He, M Yang, S Li, G Zhang, Z Ding, L Zhang… - Synthetic and systems …, 2023 - Elsevier
Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …
regulating complex internal metabolic networks. These crucial bioactive functions rely on …
Synergistic investigation of natural and synthetic C1-trophic microorganisms to foster a circular carbon economy
A true circular carbon economy must upgrade waste greenhouse gases. C1-based
biomanufacturing is an attractive solution, in which one carbon (C1) molecules (eg CO2 …
biomanufacturing is an attractive solution, in which one carbon (C1) molecules (eg CO2 …
Machine-learning from Pseudomonas putida KT2440 transcriptomes reveals its transcriptional regulatory network
Bacterial gene expression is orchestrated by numerous transcription factors (TFs).
Elucidating how gene expression is regulated is fundamental to understanding bacterial …
Elucidating how gene expression is regulated is fundamental to understanding bacterial …
Genomic footprinting uncovers global transcription factor responses to amino acids in Escherichia coli
Our knowledge of transcriptional responses to changes in nutrient availability comes
primarily from few well-studied transcription factors (TFs), often lacking an unbiased genome …
primarily from few well-studied transcription factors (TFs), often lacking an unbiased genome …
Machine learning uncovers independently regulated modules in the Bacillus subtilis transcriptome
The transcriptional regulatory network (TRN) of Bacillus subtilis coordinates cellular
functions of fundamental interest, including metabolism, biofilm formation, and sporulation …
functions of fundamental interest, including metabolism, biofilm formation, and sporulation …
[HTML][HTML] Advancing the scale of synthetic biology via cross-species transfer of cellular functions enabled by iModulon engraftment
D Choe, CA Olson, R Szubin, H Yang, J Sung… - Nature …, 2024 - nature.com
Abstract Machine learning applied to large compendia of transcriptomic data has enabled
the decomposition of bacterial transcriptomes to identify independently modulated sets of …
the decomposition of bacterial transcriptomes to identify independently modulated sets of …