Self-assembled peptide and protein amyloid nanostructures have traditionally been
considered only as pathological aggregates implicated in human neurodegenerative …

The fundamental roles that peptides and proteins play in today's biology makes it almost
indisputable that peptides were key players in the origin of life. Insofar as it is appropriate to …

Abstract α-Synuclein (α-syn) amyloid fibrils are the major component of Lewy bodies, which
are the pathological hallmark of Parkinson's disease (PD) and other synucleinopathies. High …

The aggregation of proteins into structures known as amyloids is observed in many
neurodegenerative diseases, including Alzheimer's disease. Amyloids are composed of …

Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important
pathological hallmark of Parkinson disease and several other neurodegenerative diseases …

When protein/peptides aggregate, they usually form the amyloid state consisting of cross β-
sheet structure built by repetitively stacked β-strands forming long fibrils. Amyloids are …

Maintenance of plasma membrane integrity is essential for normal cell viability and function.
Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of …

Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD);
however, its role in normal vertebrate physiology has remained unknown. Recent studies …

Abstract α-synuclein misfolding and aggregation into fibrils is a common feature of α-
synucleinopathies, such as Parkinson's disease, in which α-synuclein fibrils are a …