[HTML][HTML] Oxidative stress and mitochondrial dysfunction in early-onset and late-onset preeclampsia

R Marín, DI Chiarello, C Abad, D Rojas… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Preeclampsia is a pregnancy-specific syndrome with multisystem involvement which leads
to foetal, neonatal, and maternal morbidity and mortality. This syndrome is characterized by …

Adaptations of the human placenta to hypoxia: opportunities for interventions in fetal growth restriction

A Colson, P Sonveaux, F Debiève… - Human reproduction …, 2021 - academic.oup.com
BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Omics approaches to study formation and function of human placental syncytiotrophoblast

A Jaremek, MJ Jeyarajah, G Jaju Bhattad… - Frontiers in Cell and …, 2021 - frontiersin.org
Proper development of the placenta is vital for pregnancy success. The placenta regulates
exchange of nutrients and gases between maternal and fetal blood and produces hormones …

Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus

JJ Fisher, CL Vanderpeet, LA Bartho… - The Journal of …, 2021 - Wiley Online Library
Key points Mitochondrial dysfunction is known to occur in diabetic phenotypes including
type 1 and 2 diabetes mellitus. The incidence of gestational diabetes mellitus (GDM) is …

The impact of oxidative stress of environmental origin on the onset of placental diseases

CSM Ruano, F Miralles, C Méhats, D Vaiman - Antioxidants, 2022 - mdpi.com
Oxidative stress (OS) plays a pivotal role in placental development; however, abnormal
loads in oxidative stress molecules may overwhelm the placental defense mechanisms and …

[HTML][HTML] p66Shc-mediated oxidative stress is involved in gestational diabetes mellitus

TT Huang, WJ Sun, HY Liu, HL Ma… - World Journal of …, 2021 - ncbi.nlm.nih.gov
BACKGROUND Gestational diabetes mellitus (GDM) is associated with a heightened level
of oxidative stress, which is characterized by the overproduction of reactive oxygen species …

Differential effect of lead and cadmium on mitochondrial function and NLRP3 inflammasome activation in human trophoblast

Y Dai, X Xu, X Huo, JHN Schuitemaker… - The Journal of …, 2024 - Wiley Online Library
Heavy metals disrupt mitochondrial function and activate the NOD‐like receptor pyrin‐
containing 3 (NLRP3) inflammasome. We investigated the effect of lead (Pb)/cadmium (Cd) …

MiR-101-containing extracellular vesicles bind to BRD4 and enhance proliferation and migration of trophoblasts in preeclampsia

J Cui, X Chen, S Lin, L Li, J Fan, H Hou, P Li - Stem cell research & …, 2020 - Springer
Background Preeclampsia (PE) is a frequently occurring pregnancy disorder in the placenta,
which results in various maternal and fetal complications. The current study aims to evaluate …

Physically active pregnancies: Insights from the placenta

KB Adamo, AD Goudreau, AE Corson… - Physiological …, 2024 - Wiley Online Library
Physical activity (PA) positively influences pregnancy, a critical period for health promotion,
and affects placental structure and function in ways previously overlooked. Here, we …

Glycolysis: A fork in the path of normal and pathological pregnancy

R Gou, X Zhang - The FASEB Journal, 2023 - Wiley Online Library
Glucose metabolism is vital to the survival of living organisms. Since the discovery of the
Warburg effect in the 1920s, glycolysis has become a major research area in the field of …