Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

The skin is a complex and dynamic ecosystem that is inhabited by bacteria, archaea, fungi
and viruses. These microbes—collectively referred to as the skin microbiota—are …

Mycobacterium tuberculosis, the leading cause of death due to infection, has a dynamic and
immunomodulatory cell envelope. The cell envelope structurally and functionally varies …

In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

The discovery of the genetic code and tRNAs as decoders of the code transformed life
science. However, after establishing the role of tRNAs in protein synthesis, the field moved …

Despite enormous progress in understanding the fundamentals of bacterial gene regulation,
our knowledge remains limited when compared with the number of bacterial genomes and …

Metabolism was once relegated to the supply of energy and biosynthetic precursors, but it
has now become clear that it is a specific mediator of nearly all physiological processes. In …

Underlying cellular responses is a transcriptional regulatory network (TRN) that modulates
gene expression. A useful description of the TRN would decompose the transcriptome into …

The absence of a gold standard to determine when antibiotics induce a sterilizing cure has
confounded the development of new approaches to treat pulmonary tuberculosis (PTB). We …

Tuberculosis (TB) lesions are extremely complex and dynamic. Here, we review the multiple
types and fates of pulmonary lesions that form following infection by M ycobacterium …