Praziquantel for schistosomiasis: single-drug metabolism revisited, mode of action, and resistance
Schistosomiasis, a major neglected tropical disease, affects more than 250 million people
worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel …
worldwide. Treatment of schistosomiasis has relied on the anthelmintic drug praziquantel …
Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam
The potential impact of the Three Gorges Dam (TGD) on schistosomiasis transmission in
China has invoked considerable global concern. The TGD will result in changes in the water …
China has invoked considerable global concern. The TGD will result in changes in the water …
Reduced Efficacy of Praziquantel Against Schistosoma mansoni Is Associated With Multiple Rounds of Mass Drug Administration
Background. Mass drug administration (MDA) with praziquantel is the cornerstone of
schistosomiasis control in sub-Saharan Africa. The effectiveness of this strategy is …
schistosomiasis control in sub-Saharan Africa. The effectiveness of this strategy is …
Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni
SD Melman, ML Steinauer… - PLoS neglected …, 2009 - journals.plos.org
Background The near exclusive use of praziquantel (PZQ) for treatment of human
schistosomiasis has raised concerns about the possible emergence of drug-resistant …
schistosomiasis has raised concerns about the possible emergence of drug-resistant …
[HTML][HTML] A new global strategy for the elimination of schistosomiasis
AGP Ross, TN Chau, MT Inobaya, RM Olveda… - International Journal of …, 2017 - Elsevier
Mass drug administration utilising a single oral dose of 40 mg/kg of praziquantel (PZQ) has
been endorsed and advocated by the World Health Organisation (WHO) for the global …
been endorsed and advocated by the World Health Organisation (WHO) for the global …
Neuroschistosomiasis
Schistosomiasis (bilharzia) is a neglected tropical disease caused by digenetic trematode
platyhelminths of the genus Schistosoma. Neuroschistosomiasis is one of the most severe …
platyhelminths of the genus Schistosoma. Neuroschistosomiasis is one of the most severe …
A wake up call for urinary schistosomiasis: reconciling research effort with public health importance
D Rollinson - Parasitology, 2009 - cambridge.org
This review considers the current status of urinary schistosomiasis, caused by infection with
Schistosoma haematobium, and argues that greater research effort and focus are needed to …
Schistosoma haematobium, and argues that greater research effort and focus are needed to …
New approaches for understanding mechanisms of drug resistance in schistosomes
RM Greenberg - Parasitology, 2013 - cambridge.org
Schistosomes are parasitic flatworms that cause schistosomiasis, a neglected tropical
disease that affects hundreds of millions worldwide. Treatment and control of …
disease that affects hundreds of millions worldwide. Treatment and control of …
What is the mechanism of action of praziquantel and how might resistance strike?
PM Cupit, C Cunningham - Future medicinal chemistry, 2015 - Taylor & Francis
Background While S. mansoni and S. japonicum are associated with intestinal
schistosomiasis where mature schistosomes relocate to the mesenteric veins from the liver …
schistosomiasis where mature schistosomes relocate to the mesenteric veins from the liver …
Real-time PCR for diagnosis of imported schistosomiasis
H Guegan, J Fillaux, E Charpentier… - PLoS Neglected …, 2019 - journals.plos.org
Background The diagnosis of schistosomiasis currently relies on microscopic detection of
schistosome eggs in stool or urine samples and serological assays. The poor sensitivity of …
schistosome eggs in stool or urine samples and serological assays. The poor sensitivity of …