Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

As key developmental regulators, HOX cluster genes have varied and context-specific roles
in normal and malignant hematopoiesis. A complex interaction of transcription factors …

The nucleophosmin (NPM1) gene encodes for a multifunctional chaperone protein that is
localized in the nucleolus but continuously shuttles between the nucleus and cytoplasm …

Gain-of-function mutations in the histone acetylation “reader” eleven-nineteen-leukemia
(ENL), found in acute myeloid leukemia (AML) and Wilms tumor, are known to drive …

NUP98 and NUP214 form chimeric fusion proteins that assemble into phase-separated
nuclear bodies containing CRM1, a nuclear export receptor. However, these nuclear bodies' …

NPM1-mutated acute myeloid leukemia (AML) represents the largest molecular subgroup of
adult AML. NPM1-mutated AML is recognizable by molecular techniques and …

Acute myeloid leukemia (AML) is the most aggressive adult leukemia, characterized by
clonal differentiation arrest of progenitor or precursor hematopoietic cells. Intense preclinical …

Abstract Nucleophosmin 1 (NPM1) is commonly mutated in myelodysplastic syndrome
(MDS) and acute myeloid leukemia. Concurrent inflammatory bowel diseases (IBD) and …

Nucleophosmin (NPM1) is frequently mutated in acute myeloid leukemia, and NPM1
expression is elevated in several cancer types. NPM1 is a multifunctional oligomeric protein …

Despite advances in the clinical management of childhood acute myeloid leukemia (AML)
during the last decades, outcome remains fatal in approximately one third of patients …