The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes
The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …
mechanical and electrical junctions. Although described in some detail by light microscopy …
Determinants of myocardial conduction velocity: implications for arrhythmogenesis
Slowed myocardial conduction velocity (θ) is associated with an increased risk of re-entrant
excitation, predisposing to cardiac arrhythmia. θ is determined by the ion channel and …
excitation, predisposing to cardiac arrhythmia. θ is determined by the ion channel and …
Sodium channels in the Cx43 gap junction perinexus may constitute a cardiac ephapse: an experimental and modeling study
It has long been held that electrical excitation spreads from cell-to-cell in the heart via low
resistance gap junctions (GJ). However, it has also been proposed that myocytes could …
resistance gap junctions (GJ). However, it has also been proposed that myocytes could …
Intercalated disk nanoscale structure regulates cardiac conduction
The intercalated disk (ID) is a specialized subcellular region that provides electrical and
mechanical connections between myocytes in the heart. The ID has a clearly defined …
mechanical connections between myocytes in the heart. The ID has a clearly defined …
Connexins and disease
Inherited or acquired alterations in the structure and function of connexin proteins have long
been associated with disease. In the present work, we review current knowledge on the role …
been associated with disease. In the present work, we review current knowledge on the role …
Mechanisms of cardiac conduction: a history of revisions
Cardiac conduction is the process by which electrical excitation spreads through the heart,
triggering individual myocytes to contract in synchrony. Defects in conduction disrupt …
triggering individual myocytes to contract in synchrony. Defects in conduction disrupt …
The blinding period following ablation therapy for atrial fibrillation: proarrhythmic and antiarrhythmic pathophysiological mechanisms
Atrial fibrillation (AF) causes heart failure, ischemic strokes, and poor quality of life. The
number of patients with AF is estimated to increase to 18 million in Europe in 2050 …
number of patients with AF is estimated to increase to 18 million in Europe in 2050 …
Cx43 Associates with Nav1.5 in the Cardiomyocyte Perinexus
Gap junctions (GJs) are aggregates of channels that provide for direct cytoplasmic
connection between cells. Importantly, this connection is thought responsible for cell-to-cell …
connection between cells. Importantly, this connection is thought responsible for cell-to-cell …
Vascular endothelial growth factor promotes atrial arrhythmias by inducing acute intercalated disk remodeling
Atrial fibrillation (AF) is the most common arrhythmia and is associated with inflammation. AF
patients have elevated levels of inflammatory cytokines known to promote vascular leak …
patients have elevated levels of inflammatory cytokines known to promote vascular leak …
[HTML][HTML] Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions
G Tse, JM Yeo - IJC Heart & Vasculature, 2015 - Elsevier
Ventricular arrhythmias arise from disruptions in the normal orderly sequence of electrical
activation and recovery of the heart. They can be categorized into disorders affecting …
activation and recovery of the heart. They can be categorized into disorders affecting …