Cognitive impairment affects 40–60% of patients with multiple sclerosis. It may be present
early in the course of the disease and has an impact on a patient's employability, social …

Background Moderate correlation exists between the imaging quantification of brain white
matter lesions and cognitive performance in people with multiple sclerosis (MS). This may …

An efficient network such as the human brain features a combination of global integration of
information, driven by long-range connections, and local processing involving short-range …

Background: The fornix is the primary axonal tract of the hippocampus, connecting it to
modulatory subcortical structures. This review reveals that fornix damage causes cognitive …

Abstract Background Multiple Sclerosis (MS) associated cognitive impairment is believed to
be mostly connected with damage to gray matter. The contribution of white matter is still …

Background: Cognitive decline is age relevant and it can start as early as middle age. The
decline becomes more obvious among older adults, which is highly associated with …

In this study, we investigated whether regional distribution of white matter (WM) lesions,
normal-appearing [NA] WM microstructural abnormalities and gray matter (GM) atrophy may …

Background Up to 65% of people with multiple sclerosis (PwMS) develop cognitive deficits,
which hampers their ability to work, participating in day-to-day life and ultimately reducing …

Background As disease progression remains poorly understood in multiple sclerosis (MS),
we aim to investigate the sequence in which different disease milestones occur using a …

Background Processing speed (PS) decline is the most commonly observed cognitive deficit
in people with multiple sclerosis (MS) resulting in a significant impact on quality of life …