Opioid use disorder
Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …
New directions in the treatment of opioid withdrawal
The treatment of opioid withdrawal is an important area of clinical concern when treating
patients with chronic, non-cancer pain, patients with active opioid use disorder, and patients …
patients with chronic, non-cancer pain, patients with active opioid use disorder, and patients …
Systematic evaluation of state policy interventions targeting the US opioid epidemic, 2007-2018
Importance In response to the increase in opioid overdose deaths in the United States, many
states recently have implemented supply-controlling and harm-reduction policy measures …
states recently have implemented supply-controlling and harm-reduction policy measures …
Association of racial/ethnic segregation with treatment capacity for opioid use disorder in counties in the United States
Importance Treatment with methadone or buprenorphine is the current standard of care for
opioid use disorder. Given the paucity of research identifying which patients will respond …
opioid use disorder. Given the paucity of research identifying which patients will respond …
Socioeconomic risk factors for fatal opioid overdoses in the United States: Findings from the Mortality Disparities in American Communities Study (MDAC)
Background Understanding relationships between individual-level demographic,
socioeconomic status (SES) and US opioid fatalities can inform interventions in response to …
socioeconomic status (SES) and US opioid fatalities can inform interventions in response to …
Tackling the overdose crisis: the role of safe supply
North America is experiencing an unprecedented overdose crisis driven by the proliferation
of fentanyl and its analogues in the illicit drug supply. In 2018 there were 67,367 drug …
of fentanyl and its analogues in the illicit drug supply. In 2018 there were 67,367 drug …
Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention
ND Volkow, C Blanco - World Psychiatry, 2023 - Wiley Online Library
Substance use disorders (SUDs) are highly prevalent and exact a large toll on individuals'
health, well‐being, and social functioning. Long‐lasting changes in brain networks involved …
health, well‐being, and social functioning. Long‐lasting changes in brain networks involved …
Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal
Social isolation during opioid withdrawal is a major contributor to the current opioid
addiction crisis. We find that sociability deficits during protracted opioid withdrawal in mice …
addiction crisis. We find that sociability deficits during protracted opioid withdrawal in mice …
Patient-reported outcomes of treatment of opioid dependence with weekly and monthly subcutaneous depot vs daily sublingual buprenorphine: a randomized clinical …
Importance Patient-reported outcomes in the treatment of opioid dependence may differ
between subcutaneously administered depot buprenorphine and daily sublingual …
between subcutaneously administered depot buprenorphine and daily sublingual …
Who stays in medication treatment for opioid use disorder? A national study of outpatient specialty treatment settings
Background Maintenance treatments with medications for opioid use disorder (MOUD) are
highly effective at reducing overdose risk while patients remain in care. However, few …
highly effective at reducing overdose risk while patients remain in care. However, few …