Glutamate is the major excitatory neurotransmitter in the vertebrate central nervous system.
Once released, it binds to specific membrane receptors and transporters activating a wide …

Membrane proteins constitute the filter that controls the cellular traffic of nutrients, ions and
other essential molecules, as well as the transmission of signals across the membrane …

Voltage-gated potassium (Kv) channels each comprise four pore-forming α-subunits that
orchestrate essential duties such as voltage sensing and K+ selectivity and conductance. In …

Abstract Voltage-gated K+(Kv) channel opening repolarizes excitable cells by allowing K+
efflux. Over the last two decades, multiple Kv functions in the nervous system have been …

Potassium channels form physical complexes with solute transporters in vivo, yet little is
known about their range of possible signaling modalities and the underlying mechanisms …

Cellular biomolecular complexes including protein–protein, protein–RNA, and protein–DNA
interactions regulate and execute most biological functions. In particular in brain, protein …

Risperidone has been used to treat the symptoms of schizophrenia and to reduce its
relapse. However, the responses to treatment show great variability among patients. The …

Voltage-gated potassium (Kv) channels open in response to changes in membrane potential
to permit passage of K+ ions across the cell membrane, down their electrochemical gradient …

Abstract Dopamine (DA) transporters (DATs) are regulated by trafficking and modulatory
processes that probably rely on stable and transient interactions with neighboring proteins …

We have characterized the structural determinants of phospholamban (PLB) and sarcolipin
(SLN) self-association using site-directed mutagenesis, SDS-PAGE, and fluorescence …