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The role of m6A and m6Am RNA modifications in the pathogenesis of diabetes mellitus
The rapidly develo** research field of epitranscriptomics has recently emerged into the
spotlight of researchers due to its vast regulatory effects on gene expression and thereby …
spotlight of researchers due to its vast regulatory effects on gene expression and thereby …
[HTML][HTML] Islet transplantation: current limitations and challenges for successful outcomes
A Langlois, M **et, L Kessler, K Bouzakri - Cells, 2024 - mdpi.com
Islet transplantation is a promising approach for treating patients with unstable T1DM.
However, it is confronted with numerous obstacles throughout the various stages of the …
However, it is confronted with numerous obstacles throughout the various stages of the …
m6A-mediated gluconeogenic enzyme PCK1 upregulation protects against hepatic ischemia-reperfusion injury
S Yu, X Liu, Y Xu, L Pan, Y Zhang, Y Li, S Dong… - Hepatology, 2025 - journals.lww.com
Abstract Background and Aims: Ischemia-reperfusion (I/R) injury frequently occurs during
liver surgery, representing a major reason for liver failure and graft dysfunction after …
liver surgery, representing a major reason for liver failure and graft dysfunction after …
Emerging role of epitranscriptomics in diabetes mellitus and its complications
X Geng, Z Li, Y Yang - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetes mellitus (DM) and its related complications are among the leading causes of
disability and mortality worldwide. Substantial studies have explored epigenetic regulation …
disability and mortality worldwide. Substantial studies have explored epigenetic regulation …
The YTHDC1/GLUT3/RNF183 axis forms a positive feedback loop that modulates glucose metabolism and bladder cancer progression
B Yan, X Li, M Peng, Y Zuo, Y Wang, P Liu… - … & Molecular Medicine, 2023 - nature.com
Aberrant glucose metabolism is a characteristic of bladder cancer. Hyperglycemia
contributes to the development and progression of bladder cancer. However, the underlying …
contributes to the development and progression of bladder cancer. However, the underlying …
[HTML][HTML] Milk exosomal microRNAs: postnatal promoters of β cell proliferation but potential inducers of β cell de-differentiation in adult life
BC Melnik, G Schmitz - International Journal of Molecular Sciences, 2022 - mdpi.com
Pancreatic β cell expansion and functional maturation during the birth-to-weaning period is
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …
driven by epigenetic programs primarily triggered by growth factors, hormones, and nutrients …
[HTML][HTML] N6-methyladenosine (m6A) methylation in kidney diseases: mechanisms and therapeutic potential
Y Sun, D **, Z Zhang, H Ji, X An, Y Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Abstract The N6-methyladenosine (m6A) modification is regulated by methylases, commonly
referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and …
referred to as “writers,” and demethylases, known as “erasers,” leading to a dynamic and …
The role of M6a modification in type 2 diabetes: A systematic review and integrative analysis
YL Li, Y Zhang, N Chen, YX Yan - Gene, 2024 - Elsevier
This study focuses on the latest developments in the studies of m 6 A modification and
provides an up-to-date summary of the association between m 6 A modification and type 2 …
provides an up-to-date summary of the association between m 6 A modification and type 2 …
Reduction of mRNA m6A associates with glucose metabolism via YTHDC1 in human and mice
K Yang, J Sun, Z Zhang, M **ao, D Ren… - Diabetes research and …, 2023 - Elsevier
Abstract Aims N 6-methyladenosine (m 6 A) in mRNA is involved in glucose metabolism. Our
goal is to investigate the relationship of glucose metabolism, m 6 A and YTH domain …
goal is to investigate the relationship of glucose metabolism, m 6 A and YTH domain …
The epigenetic regulation of RNA N6-methyladenosine methylation in glycolipid metabolism
H Yang, Y Li, L Huang, M Fang, S Xu - Biomolecules, 2023 - mdpi.com
The highly conserved and dynamically reversible N6-methyladenine (m6A) modification has
emerged as a critical gene expression regulator by affecting RNA splicing, translation …
emerged as a critical gene expression regulator by affecting RNA splicing, translation …