GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors,
are the largest receptor family in the human genome, with≈ 800 members. GPCRs regulate …

Louis Pasteur once famously said 'in the fields of observation chance favors only the
prepared mind'. Much of chance is being in the right place at the right time. This is …

In the nervous system, G protein-coupled receptors (GPCRs) control neuronal excitability,
synaptic transmission, synaptic plasticity, and, ultimately, behavior through spatiotemporally …

The 3′, 5′-cyclic adenosine monophosphate (cAMP) mediates the effects of sympathetic
stimulation on the rate and strength of cardiac contraction. Beyond this pivotal role, in …

Gprotein-coupled receptors (GPCRs) regulate several physiological and pathological
processes and represent the target of approximately 30% of Food and Drug Administration …

G protein-coupled receptors (GPCRs) regulate every aspect of kidney function by mediating
the effects of various endogenous and exogenous substances. A key concept in GPCR …

For many decades, our understanding of G protein-coupled receptor (GPCR) activity and
cyclic AMP (cAMP) signaling was limited exclusively to the plasma membrane. However, a …

The metabolic network's primary sources of free fatty acids (FFAs) are long-and medium-
chain fatty acids of triglyceride origin and short-chain fatty acids produced by intestinal …

G protein-coupled receptors (GPCRs) are the most frequent target of currently approved
drugs and play a central role in both physiological and pathophysiological processes …

White and brown adipocytes are central mediators of lipid metabolism and thermogenesis,
respectively. Their function is tightly regulated by all three β‐adrenergic receptor (β‐AR) …