This review analyses the literature concerning non-fluorescent and fluorescent probes for
nucleic acid imaging in fixed and living cells from the point of view of their suitability for …

Molecular beacons are sensitive fluorescent probes hybridizing selectively to designated
DNA and RNA targets. They have recently become practical tools for quantitative real-time …

Synthetic chemistry has been central to the design of modern methods of genetic analysis. In
this article, we discuss the underlying chemistry and biophysical principles that have been …

Methods for the fluorescent detection of specific sequences of double strand DNA in
homogeneous solution may be useful in the field of human genetics. A series of hairpin …

A general method for preparing optically pure guanidine-based γ-peptide nucleic acid
(γGPNA) monomers for all four natural nucleobases (A, C, G, and T) is described. These …

Nucleic acids are an attractive platform for organizing molecular self-assembly because of
their specific nucleobase interactions and defined length scale. Routinely employed in the …

We describe the synthesis and study of multicolor quenched autoligating (QUAL) probes for
identification and discrimination of closely related RNA and DNA sequences in solution and …

Modified nucleic acids have a wide range of applications in many areas of biochemistry. In
particular, fluorescence-based nucleic acid systems have been studied extensively for their …

We have designed a strategy to generate a light‐up fluorophore–aptamer pair based on a
down‐modification of a conventional DNA‐staining dye to suppress its affinity to the original …

Novel fluorogenic DNA probes are described. The probes (called Pleiades) have a minor
groove binder (MGB) and a fluorophore at the 5′-end and a non-fluorescent quencher at …