MicroRNAs (miRNAs) represent a class of small, non-coding RNAs with the main roles of
regulating mRNA through its degradation and adjusting protein levels. In recent years …

Implementation of biomarkers in sepsis and septic shock in emergency situations, remains
highly challenging. This viewpoint arose from a public–private 3-day workshop aiming to …

Systematic characterization of the cancer microbiome provides the opportunity to develop
techniques that exploit non-human, microorganism-derived molecules in the diagnosis of a …

Background The identification of critically ill COVID-19 patients at risk of fatal outcomes
remains a challenge. Here, we first validated candidate microRNAs (miRNAs) as biomarkers …

Post-transcriptional regulation of p53, by the microRNA miR-125b and the RNA-binding
protein HuR, controls p53 expression under genotoxic stress. p53 mRNA translation is …

Host innate immunity is the major player against continuous microbial infection. Various
pathogenic bacteria adopt the strategies to evade the immunity and show resistance toward …

The vectored Ebola vaccine rVSVΔG-ZEBOV-GP elicits protection against Ebola Virus
Disease (EVD). In a study of forty-eight healthy adult volunteers who received either the …

Introduction Patients with community-acquired pneumonia (CAP) undergo a dysregulated
host response that is related to mortality. MicroRNAs (miRNAs) participate in this response …

The influenza A virus (IAV) NS1 protein is one of the major regulators of pathogenicity, being
able to suppress innate immune response and host protein synthesis. In this study we …

Die Identifikation eines Biomarkers, der idealerweise eine perfekte Sensitivität und Spezifität
mitbringt, um eine Inflammation von einer Infektion zu unterscheiden, ist bis heute nicht …