Oxidative stress (OS) disrupts the chemical integrity of macromolecules and increases the
risk of neurodegenerative diseases. Fisetin is a flavonoid that exhibits potent antioxidant …

Ubiquitin–proteasome system (UPS) is a selective proteolytic system that is associated with
the expression or function of target proteins and participates in various physiological and …

Neurodegenerative diseases (NDDs) are a class of neurological disorders marked by the
progressive loss of neurons that afflict millions of people worldwide. These illnesses affect …

Introduction In the field of bioconjugates, the focus on antibody–drug conjugates (ADCs)
with novel payloads beyond the traditional categories of potent cytotoxic agents is …

Wide experimental evidence has been provided in the last decade concerning the
neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders …

The proteasome system is a large and complex molecular machinery responsible for the
degradation of misfolded, damaged, and redundant cellular proteins. When proteasome …

Neurodegenerative diseases are emerging as a global health concern in the current
scenario, and their association with mitochondrial defects has been a potential area of …

Defective proteostasis is associated with the gradual accumulations of misfolded proteins
and is a hallmark of many age-associated neurodegenerative diseases. In the aged brain …

Abstract Ubiquilin 4 (UBQLN4) is an important member of the ubiquitin-like protein family. An
increasing number of studies have shown that UBQLN4 is an important regulator of …

The ubiquitin–proteasome system (UPS) controls protein homeostasis to maintain cell
functionality and survival. Neurogenesis relies on proteasome function, and a defective …